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NFL Week 15 Picks Against the Spread: Bills vs. Lions Showdown Headlines Best Bets for Week 15

Contributors
Published December 11, 2024
21 min read
  • The NFL playoffs are one month away

  • The Steelers and Broncos are tied for the best record ATS (10-3)

  • The Titans are a league-worst 2-11 ATS

While it might feel like the NFL season has only just begun, there are now just four weeks of action left until the postseason arrives.

The Detroit Lions and Kansas City Chiefs lead the NFL in odds to win the Super Bowl, while the once-hapless Carolina Panthers are on fire against the spread and should’ve taken down the Philadelphia Eagles last week.

As the intensity increases and the stakes are raised around the league, we’ve made picks against the spread for every NFL game in Week 15.

Here are our best NFL Week 15 bets.

Picks ATS 2024 NFL Stats

Look, we’d be lying if we said we weren’t disappointed to still be under .500. The record has been positive ever since a terrible few weeks to start the season, but we’re still searching for the late-year surge to push us into the green.

We have faith that a surge will come this week. Let’s do this thing!

  • Last week’s record: 5-8 (38.5 percent)

  • 2024 record: 96-108-3 (47.1 percent)

NFL Week 15 Predictions and Odds

Odds from BetMGM Sportsbook. Use our promo code WSNSPORTS and claim your welcome bonus at BetMGM today: Get Up to $1,500 in Bonus Bets!*

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Matchup Pick
Rams vs. 49ers Rams +2.5 (-110)
Chiefs vs. Browns Browns +6.5 (-115)
Bengals vs. Titans Bengals -5 (-115)
Commanders vs. Saints Commanders -7.5 (-110)
Ravens vs. Giants Giants +15 (-110)
Cowboys vs. Panthers Cowboys +1 (-110)
Jets vs. Jaguars Jets -3 (-115)
Dolphins vs. Texans Dolphins +3 (-115)
Colts vs. Broncos Colts +4 (-110)
Bills vs. Lions Bills +2 (-110)
Steelers vs. Eagles Steelers +5 (-110)
Patriots vs. Cardinals Cardinals -4.5 (-110)
Buccaneers vs. Chargers Buccaneers +3 (-115)
Packers vs. Seahawks Packers -3 (-105)
Bears vs. Vikings Bears +7 (-115)
Falcons vs. Raiders Falcons -4.5 (-105)

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NFL Picks Against the Spread

Rams vs. 49ers - Dec. 12, 8:15 PM ET 

  • Spread: Rams +2.5 (-110), 49ers -2.5 (-110)

  • Moneyline: Rams +120, 49ers -140

  • Total: Over/under 48.5 (-110/-110)

We’ve reiterated throughout the year that the Rams, when healthy, are an incredibly dangerous team. They proved us correct with their thrilling 44-42 win over the Buffalo Bills last week and have now won six of their last eight games, replicating the late-season run they went on a year ago. The positives are that their team is getting healthy, and their defense is playing better than it did at the start of the year (despite just allowing 42 points).

Brock Purdy played an outstanding game with his back against the wall in an annihilation of the Chicago Bears last weekend. The Niners’ long-term prospects are still in question due to injuries to key players and the team’s unraveling chemistry, as evidenced by Deebo Samuel’s recent tweets, but they will be sure to get up for a division rival in an in-state matchup in primetime on Thursday.

The Rams are on the road against another NFC West foe, which usually spells trouble. However, they have found their stride, while the Niners’ lack of health is still a major concern despite their recent success against Chicago. This has the makings of a low-scoring affair that cashes the under, but we like the Rams.

Rams vs. 49ers pick: Rams +2.5 (-110) at BetMGM

Chiefs vs. Browns - Dec. 15, 1:00 PM ET 

  • Spread: Chiefs -6.5 (-105), Browns +6.5 (-115)

  • Moneyline: Chiefs -300, Browns +240

  • Total: Over/under 45 (-110/-110)

For as dominant as they are and have been, the Chiefs sure do give their fans their share of thrills and excitement. 10 of their 12 wins came in one-score games, but while many would consider that blind luck, it’s fair to say that no team in the league is better and more comfortable within the margins than they are. Patrick Mahomes and Deandre Hopkins have a strong connection, and their defense shows up in big moments against big teams.

Cleveland’s defensive identity is gone, and they now rely on the playmaking ability of Jameis Winston to win them games. That formula isn’t conducive to long-term success, given his propensity to turn the ball over, but it will both play them into and out of a variety of games. The Browns are only 2-4 at home but covered in two of their last four games, which is a sign of some improvement.

The Chiefs aren’t good against the spread historically and are just 5-8 (38.5 percent) this season. They should win this game, but getting the Browns at 6.5 could prove to be a worthy investment with how well Winston has moved the ball, and since the Chiefs’ defense wasn’t great against inferior opponents over the last couple of months.

Chiefs vs. Browns pick: Browns +6.5 (-115) at BetMGM

Bengals vs. Titans - Dec. 15, 1:00 PM ET 

  • Spread: Bengals -5 (-115), Tians +5 (-105)

  • Moneyline: Bengals -225, Titans +190

  • Total: Over/under 48 (-110/-110)

It’s a crime that Joe Burrow is having the season that he is, and the Bengals are only 5-8 and relying on hopes and dreams to sneak into the seventh seed in the AFC playoffs. Burrow leads the NFL in passing yards and touchdowns and is second in QBR, but his defense gives up the fourth-most points per game. He also gets no support from the rushing attack or defense, and can only rely on Ja’Marr Chase to show up in important spots.

Just when it seemed as if Will Levis and the Titans were in control of their season after Levis made a series of nice throws against the Commanders, they lost 10-6 to the Mac Jones-led Jaguars. Tennessee is horrible straight up and against the spread and can’t get its offense and defense to play well at the same time. Looking at their previous matchups with high-powered offense, they lost by 16, lost by 24, lost by 38, won by five, and lost by 23.

Because of the results we outlined above, the Bengals should be able to pull away in this game. Their defense is abysmal, but the Titans can’t be trusted to score 13 points week-to-week. We hate trusting Cincy with anything this season, but Burrow is playing outstandingly well.

Bengals vs. Titans pick: Bengals -5 (-115) at BetMGM

Commanders vs. Saints - Dec. 15, 1:00 PM ET 

  • Spread: -7.5 (-110), Saints +7.5 (-110)

  • Moneyline: Commanders -375, Saints +300

  • Total: Over/under 43 (-110/-110)

Marshon Lattimore is expected to make his Commanders debut against a team he knows all too well, and one that is down its starting quarterback. Jayden Daniels is no longer dealing with a rib injury, and the running game was utterly dominant in their most recent wins over the Tennessee Titans. Washington just took its bye week and should come out refreshed and ready to make its final playoff push.

The Saints have been incredibly disappointing on both sides, injuries or no injuries. It just so happens that they’ll now likely start Jake Haener or Spencer Rattler, neither one of which gives them a reasonable chance of winning. Alvin Kamara has a great opportunity against a terrible run defense, but it’s hard to find other positives for New Orleans. 

This one is simple. The Commanders played long enough before their bye week that they shouldn’t be rusty coming out on the other side, and they should also be better against both pass and run with Lattimore on the field.

Commanders vs. Saints pick: Commanders -7.5 (-110) at BetMGM

Ravens vs. Giants - Dec. 15, 1:00 PM ET 

  • Spread: Ravens -15 (-110), Giants +15 (-110)

  • Moneyline: Ravens -1200, Giants +750

  • Total: Over/under 43.5 (-110/-110)

The Ravens are also coming off of a bye week, but the difference is that they had some soul-searching to do. They lost most of their matchups with true contenders and have the same record as the Denver Broncos despite having much better PR, and that’s largely down to their terrible pass defense. Lamar Jackson and Derrick Henry have both been outstanding, but the final product often doesn’t match the sum of the parts.

The Giants are just flat-out horrible. They lost eight straight games and scored 17 or fewer points in three of their last four games, only managing 11 in their most recent loss to the Saints. There’s not a single thing they do well at this stage, so we won’t even bother elaborating further.

This is a huge line to cover for a team that knows it doesn’t need to play well to win this game. The Giants are fairly pathetic right now, but Baltimore’s secondary has been terrible. This 15-point line will leave the backdoor cover wide open, and we’d back the Giants to cover in a game they have no shot of winning.

Ravens vs. Giants pick: Giants +15 (-110) at BetMGM

Cowboys vs. Panthers - Dec. 15, 1:00 PM ET 

  • Spread: Cowboys +1 (-110), Panthers -1 (-110)

  • Moneyline: Cowboys +100, Panthers -120

  • Total: Over/under 42.5 (-110/-110)

Cooper Rush has had his moments filling in for Dak Prescott—the problem is predicting whether the next moment will be great or awful. A positive sign is that Rico Dowdle ran the ball 18 times for 131 yards last week, uplifting what had been the league’s worst ground game. Micah Parsons looks incredibly frustrated with an underperforming defense and one that just lost DeMarvion Overshown to a knee injury, which is why the spread is where it is.

Bryce Young is playing with confidence, swagger, and poise. His time on the beach was clearly for the best, because the player that is on the field looks like the one that lit up the college football skies at the University of Alabama. Chuba Hubbard has also continued his strong season, while the defense improved to 24th in EPA per play over the last month (and yes, that is an improvement for Carolina).

The Cowboys are down and out, but they are a proud team when it comes to proving themselves against inferior opposition. The question is if Young’s improved level of play will be enough to help the Panthers spring the “upset,” even though they’re favored to win. They almost took down the Eagles last week, but we’d still lean toward the Cowboys.

Cowboys vs. Panthers pick: Cowboys +1 (-110) at BetMGM

Jets vs. Jaguars - Dec. 15, 1:00 PM ET 

  • Spread: Jets -3 (-115), Jaguars +3 (-105)

  • Moneyline: Jets -185, Jaguars +150

  • Total: Over/under 40.5 (-110/-110)

The Jets are the gift that keeps on giving! They are now 3-10 just a couple of months after Aaron Rodgers said they needed to get used to “dominating” their opponents and are just 4-9 (30.8 percent) against the spread, which is tied with the Giants for the second-worst mark in the sport. Their defense has easily been one of the 10 worst in the league, and Aaron Rodgers is incapable of pushing the ball down the field.

It’s a crime that the Jaguars won last week despite Mac Jones going 23/31 for 220 yards, two interceptions, and no touchdowns, and the team managing 10 total points. They have no offensive cohesion to speak of with Jones under center and were flat-out terrible on defense all year until last week.

We called the Jets the most overrated team in the league before the season started and often faded them when others didn’t… but we can’t take Mac Jones and this defense at just a field goal, even if they are at home. The Jets’ personnel is still better, and they really, REALLY should be capable of covering this line.

Jets vs. Jaguars pick: Jets -3 (-115) at BetMGM

Dolphins vs. Texans - Dec. 15, 1:00 PM ET 

  • Spread: Dolphins +3 (-115), Texans -3 (-105)

  • Moneyline: Dolphins +125, Texans -150 

  • Total: Over/under 47 (-110/-110)

The Dolphins won four of their last five games and scored at least 23 points in six of seven games since Tua Tagovailoa returned to the lineup. They beat the Jets 32-26 in overtime last weekend and have found great success throwing the ball, albeit in less of a downfield style than they did last year. The biggest question is if their defense will continue their improved level of play which has them hanging around the top 10 in EPA per play over the last month.

C.J. Stroud and company enjoyed a much-needed bye week last week after they picked up just three wins in seven games. They’re still a dangerous team at 8-5, but they’ve been limited offensively and failed to control games defensively. It’s a very limited sample size, but they lost to the Panthers outright last year after their bye week in Demeco Ryans and Stroud’s first years in Houston.

Miami won’t mind going on the road to Houston since it will get to play in a dome. Tagovailoa has completed passes at an elite level since he returned to action, while the Texans do a better job at disrupting opposing QBs than any team in football. This feels like yet another close game, but we like the Dolphins to continue their impressive run of form.

Dolphins vs. Texans pick: Dolphins +3 (-115) at BetMGM

Colts vs. Broncos - Dec. 15, 4:25 PM ET 

  • Spread: Colts +4 (-110), Broncos -4 (-110)

  • Moneyline:  Colts +165, Broncos -200

  • Total: Over/under 44.5 (-110/-110)

The Colts are clinging to their AFC playoff hopes at 6-7 and fresh off a one-point win against the New England Patriots. Anthony Richardson has been hit or miss since he returned to the lineup and continues to flash both the potential and inconsistency that defined his young career. Indy is coming off of a bye week and has a smart coach in Shane Steichen, but they are still undermanned. 

A lot has been made of the “incredible” season that Bo Nix has had, yet he’s only 23rd in EPA per play among qualified quarterbacks. What Nix has done extremely well is get the ball out of his hands quickly and avoid turnovers (barring his last game), while Denver’s defense leads the entire league in EPA per play. They too are coming off of a bye week, which makes this just as much of a battle between coaches as it does players.

Denver is holding onto the seventh seed in the AFC, while Indy (and the Dolphins) are in hot pursuit. Denver has a much better defense, whereas Indy is a bit of a wild card with Richardson. Four points might prove to be too much against an intelligent coach with nothing to lose. 

Colts vs. Broncos pick: Colts +4 (-110) at BetMGM

Bills vs. Lions - Dec. 15, 4:25 PM ET 

  • Spread: Bills +2 (-110), Lions -2 (-110)

  • Moneyline: Bills +100, Lions -130

  • Total: Over/under 55 (-105/-115)

Points will be scored in this matchup. Josh Allen just racked up six total TDs in his last outing and gets to take his Bills on the road to a dome, offering them a reprieve from the usual wintery conditions of upstate New York. The Bills’ D just gave up 44 points to the Rams but also showed up against the Chiefs and the Niners in the weeks before.

This is the most important game of Detroit’s season. Not from a standings perspective, but for them to prove that they can beat high-scoring contenders late in the season. They are firing on all cylinders and are 9-4 (69.2 percent) against the spread despite being favored in all but one game thus far.

Both teams gave their all until the final second last week. Now, the explosive offenses will have to take on physical and aggressive defenses, both of which are comfortably in the top 10 as far as best units in the NFL. We’re looking for Allen to cement his NFL MVP season with an upset win (but would still take the points to be safe).

Bills vs. Lions pick: Bills +2 (-110) at BetMGM

Steelers vs. Eagles - Dec. 15, 4:25 PM ET 

  • Spread: Steelers +5 (-110), Eagles -5 (-110)

  • Moneyline: Steelers +185, Eagles -225

  • Total: Over/under 42.5 (-110/-110)

Pittsburgh won seven of its last eight games and cruised past the Cleveland Browns last week thanks to the three turnovers forced by its defense. Russell Wilson has been one of the five best quarterbacks in the league during his time on the field, while the defense forced more turnovers per game than any team in football. They don’t have to travel far for this “road” game and know exactly what it’s like to face physical, run-first teams with dual-threat QBs (a la the Ravens).

Philly should have lost to the Panthers last week and seems to have a chemistry issue with Jalen Hurts and A.J. Browns, the former of which has not seen the field well in recent weeks. Daquon Barkley is playing out of his skin, and the Eagles can’t fall into the same trap the Ravens did when they faced Pittsburgh as Derrick Henry only carried the ball 13 times for 65 yards. Philly’s defense was exceptional recently and will need to win the line of scrimmage.

This is our favorite matchup of the weekend because of the physicality that both teams bring to the table. Most people would take Hurts over Wilson in a vacuum, but the latter has been the better player recently. Both defenses are strong, and a five-point line—regardless of who is favored—is just too many points, especially since Mike Tomlin is the best coach ATS as an underdog in league history.

Steelers vs. Eagles pick: Steelers +5 (-110) at BetMGM

Patriots vs. Cardinals - Dec. 15, 4:25 PM ET 

  • Spread: Patriots +4.5 (-110), Cardinals -4.5 (-110)

  • Moneyline: Patriots +180, Cardinals -225

  • Total: Over/under 46 (-110/-110)

The Patriots and Drake Maye head into the matchup fresh off of a much-needed bye week following three straight losses. The rookie QB is the most effective scrambler in the league and made a number of big plays, but his youth and inexperience also led to him making repeated mistakes and costly turnovers. Jerod Mayo’s defense also started the year poorly and got worse as the year progressed.

Kyler Murray led the league in QBR until he dropped a dud in a 30-18 loss to the Seahawks last week. Arizona dropped third in the NFC West as a result and is now at serious risk of missing the playoffs after they had a hold on a top-four seed just a couple of weeks ago. They are also on a three-game losing streak and lost the defensive solidarity they showed during their four-game winning streak from Weeks 7-10.

A bye week this late in the season is great for players, but Mayo has not done anything to suggest that he is a great head coach. Coaching is amplified during extended periods of rest, and this could be a situation where the time off actually works against the team’s best interests. The Cardinals are cold, but they are also desperate and have the best player in the matchup by a wide margin.

Patriots vs. Cardinals pick: Cardinals -4.5 (-110) at BetMGM

Buccaneers vs. Chargers - Dec. 15, 4:25 PM ET 

  • Spread: Buccaneers +3 (-115), Chargers -3 (-105)

  • Moneyline: Buccaneers +125, Chargers -150

  • Total: Over/under 46 (-110/-110)

If the Bucs have proven anything this season, it’s that they are tough to put away. They won three straight games and took the Chiefs, Niners, and Ravens to the wire in close losses. Baker Mayfield is third in passing touchdowns and fourth in passing yards and will make plays, putting the onus to answer the call on Tampa’s weak secondary.

The Chargers gave up a league-best 15.9 points per game, but hold on just a second—looking at the great quarterbacks they faced, they surrendered an average of 21.5 points. Mayfield might not be elite, but his numbers are, and the Bucs will put the ball in his hands without any hesitation. Justin Herbert does not have any real weapons to aid him in the passing game, and he only threw one touchdown in the last three games (though he only has one INT all year).

The three-point line for an LA team that is home might seem puzzling, but LA is a team that plays within the margins and has a very low offensive ceiling, particularly with Herbert and Ladd McConkey banged up and J.K. Dobbins out injured. The Bucs recently moved into first place in the NFC South and have a chance to take advantage of the Falcons’ struggles.

Buccaneers vs. Chargers pick: Buccaneers +3 (-115) at BetMGM

Packers vs. Seahawks - Dec. 15, 8:20 PM ET 

  • Spread: Packers -3 (-105), Seahawks +3 (-115)

  • Moneyline: Packers -150, Seahawks +125

  • Total: Over/under 46.5 (-110/-110)

If it weren’t for the seasons that the Lions and Vikings are having, the Packers would be viewed as potentially the scariest team in the NFL. Instead, they’re only third in the pecking order within their own division. That said, they deftly blended their running and passing games and lost four games (to the Lions twice, Vikings, and Eagles) by a combined average of just five points. 

The formula for Seattle is simple: let Geno Smith air the ball out so long as he does not commit multiple turnovers, and play solid defense. That game plan helped the Seahawks win four straight games, the most recent of which came in a 30-18 result over the Cardinals. Their defense was outstanding over the last month but will be put to the test against a Packers team that is third in yards per play (6.3).

We here are big fans of the Seahawks, but there’s a glaring issue here. Smith and Jordan Love somewhat mirror each other in skill set and ability, but Green Bay is significantly better on defense. They also got extra rest since they played on Thursday night last week, and the Seahawks are only 3-4 at home.

Packers vs. Seahawks pick: Packers -3 (-105) at BetMGM

Bears vs. Vikings - Dec. 16, 8:00 PM ET 

  • Spread: Bears +7 (-115), Vikings -7 (-105)

  • Moneyline: Bears +260, Vikings -350

  • Total: Over/under 43.5 (-110/-110)

Predicting the Bears is simply impossible at this point… unless that prediction involves disappointment, in which case we can promise, there will be plenty. The Bears were dominated by the Niners last week, 38-13, as Caleb Williams’ hot streak came to a screeching halt. Their talented defense went from terrific at the beginning of the season to awful as of late, and they now get a division rival that excels on both sides. 

Minnesota is in the conversation for the most consistent team in the league. They just hung 41 points on the Falcons last week thanks to Brian Flores’ defense forcing more turnovers and Sam Darnold continuing to play like a borderline MVP candidate. They needed overtime to beat the Bears 30-27 when they met earlier in the season, though that game only ended up so close because Chicago won the fourth quarter 17-3.

Minnesota proved that it could take a comfortable lead over the Bears the last time they met. However, the Bears are still professionals, and professionals don’t like getting embarrassed. They’ll get to play in a dome on Monday and are an attractive bet because they get the full seven points. 

Bears vs. Vikings pick: Bears +7 (-115) at BetMGM

Falcons vs. Raiders - Dec. 16, 8:30 PM ET 

  • Spread: Falcons -4.5 (-105), Raiders +4.5 (-115)

  • Moneyline: Falcons -225, Raiders +185

  • Total: Over/under 44 (-110/-110)

Kirk Cousins might be a double agent. The 36-year-old seems to have lost the comfort he regained and now has a grotesque eight interceptions and zero touchdowns in his last four games, all of which were losses. Atlanta’s defense didn’t do him any favors either and ranks 24th in yards allowed per point and 25th in points allowed per game.

In another turn at quarterback, Aidan O’Connell suffered a bone bruise last weekend and could be benched for Desmond Ridder. The change to Sincere McCormick at running back did very little, and they gave up 420 total yards of offense to the Bucs last week.

Look, the Raiders are terrible all over the field, and there aren’t many opportunities to potentially fade Desmond Ridder. This is a no-brainer, no matter how terrible Cousins and the Falcons have been recently.

Falcons vs. Raiders pick: Falcons -4.5 (-105) at BetMGM

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Grant Mitchell

Grant Mitchell

Sports Betting Analyst & On-Air Host

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Grant is a sports and sports betting journalist who prides himself on delivering breaking news and insightful analyses of the industry. Grant graduated from Virginia Tech in 2021 and is feverishly pursuing his ambitions in the sports betting field. In his free time, Grant can be found passionately watching sports, doing a workout, or searching for adventure with his friends.
Email: [email protected]
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Education: Bachelor in Sports Media and Analytics
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