Titans vs. Bills Picks, Predictions & Player Props: Chance for Bills to Run Up the Score

• James Cook is expected to play for the Bills

• Tony Pollard is averaging 4.3 YPC

• The Titans are allowing the fewest yards per game in the league this season

The Tennessee Titans will travel north as they look to salvage their season against the AFC East leading Buffalo Bills. While these two teams are unevenly matched, there are a ton of great bets on the board. 

Titans vs. Bills Odds

Below are the odds for the Titans vs. Bills game from Caesars Sportsbook. Sign up with Caesars using our promo code WSN1000 and get a $1,000 First Bet Offer OR $250 in Bonus Bets.

Titans vs. Bills Predictions

The Tennessee Titans enter this game desperate for a win this weekend, but they will head home disappointed.

The Titans had a chance to save their season against a banged-up Colts team in Week 6 but once again fell flat. The defense was solid, but the offense failed to do much against the Colts. That is primarily due to the poor play of Will Levis, who may not be the quarterback the Titans hoped he would be.

Levis has shown some flash but not much growth since debuting last season. The turnovers remain a significant problem, and he is struggling to adjust to the speed of NFL defenses. Tennessee's only win came in a game in which the young quarterback left with an injury after just four pass attempts.

Things won’t get any easier for Levis and the Titans in Buffalo on Sunday. The Bills' defense has been without three top players but has continued to play well. The unit looked especially sharp last week, helping Buffalo hold off Aaron Rodgers and the Jets with a critical late-game interception.

The Titans' defense has been surprisingly strong over the first six weeks, but they will have their hands full against Josh Allen and the Bills. The team could have Amari Cooper on the field after acquiring the receiver from the Browns this week, adding badly needed depth to the receiving corps. Reports also indicate that standout running back James Cook will likely return to the field, giving Buffalo one of their top weapons back. 

Titans vs. Bills My Pick

• My Pick: Bills -9.5 (-110) at Caesars Sportsbook

The Bills have far more talent, and it will show in this Sunday's matchup. Expect Will Levis to struggle once again, turning the ball over at least twice. That will give Josh Allen and the Bills’ offense plenty of chances to run up the score, which they will do.

The Titans have the look of a team that is abandoning hopes to compete this season. The poor play of Levis could mean a long and painful rebuild for the franchise, which is hanging over the head of this locker room. That will lead to another ugly outing, allowing this high spread to be easily covered.

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Titans vs. Bills Best Prop Bets

Tony Pollard Over 62.5 Rush Yards (-119) at Caesars Sportsbook

Tony Pollard is the lone bright spot for the Titans offense this season. The former Cowboy is having a fantastic season, averaging 4.3 YPC and leading the team with 339 yards. He has rushed for 80+ yards in two straight games and will do so again tonight.

The Bills' defense has been tough this season, but they rank in the bottom ten of the league against the run. With Levis struggling, the Titans will be sure to pound the ground with Pollard, even after the Bills jump out to an early lead.

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James Cook Anytime TD Scorer (+104) at Caesars Sportsbook

James Cook has been dealing with an injury but is back to being a full participant at practice, suggesting he will play on Sunday. The 25-year-old has been fantastic for the Bills this season, especially in the red zone. Cook has five touchdowns over his last four games, and he will add to that total tonight.

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Bills FG First Scoring Play (+320) at Caesars Sportsbook

The Titans will take time to get points on the board, assuming they do at all.

The Bills’ offense will get a major boost with Cook back on the field, but this Titans’ defense is better than most people realize. They lead the league in yards allowed per game and start strong, though the team’s poor offense usually leads to the unit being fatigued.

Expect the Bills to drive the ball easily, but struggle against the Tennessee defense in the red zone early. 

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How to Watch Titans vs. Bills

• When: Sunday, October 20 at 1:00 PM EST

• Where: Highmark Stadium in Orchard Park, NY

• Where to Watch: CBS, NFL Sunday Ticket

Titans vs. Bills Best Promos and Sportsbooks

Check out the best NFL promos and NFL betting sites available in the U.S. for NFL Sunday's matchup between the Tennessee Titans and Buffalo Bills. We have listed some of our favorites in the table below.

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Titans vs. Bills Injuries

Tennessee Titans Injuries

• T'Vondre Sweat DT - Questionable

• Keondre Coburn DT - Doubtful

• L'Jarius Sneed CB - Questionable

• Treylon Burks WR - Questionable

• Ernest Jones IV LB - Questionable

Buffalo Bills Injuries

• Dalton Kincaid TE - Questionable

• Ray Davis RB - Questionable

• Mack Hollins WR - Questionable

• Taron Johnson CB - Questionable

• DaQuan Jones DT - Questionable

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