Steelers vs Bills Predictions, Odds, Picks NFL Week 5

• The Pittsburgh Steelers will start rookie QB Kenny Pickett under center on Sunday
• After four weeks, Buffalo has the number one ranked defense and the third-best offense
• Watch Steelers vs Bills live on Sunday, October 9, 2022, at 1:00 PM ET on CBS

Steelers vs Bills Odds Week 5

Odds taken from DraftKings. Click on the links below to head to the sportsbook and place your bet.

Our Picks

Point Spread: Pittsburgh Steelers +14 (-110) at DraftKings

Over/Under: Over 47.5 (-110) at BetMGM

Money Line: Buffalo Bills (-950) at FanDuel

Chances are the Buffalo Bills are going to beat the Pittsburgh Steelers on Sunday in Week 5, but this bet is whether you believe they will do it by more than two touchdowns, something that has yet to happen this tough season.

The Steelers have lost the last three games in a row, but one of those losses was by a field goal, another by four points, and the third by twelve, though none of those opponents (New England Patriots, Cleveland Browns, New York Jets) are having a breakout season either.

An important thing to consider is that the Steelers are now without star LB T.J. Watt due to a pectoral injury, and this has affected not only the defensive line’s ability to rush the opposing quarterbacks (the team has 10 total sacks) but also it forces Pittsburgh’s secondary to cover longer as a result.

A key matchup to watch in this battle will be against Steelers rookie receiver George Pickens and Bills rookie CB Kaiir Elam (who could be filling in for the injured starting CB Christian Benford (hand) who is listed as questionable to play in this one) the two NFL newbies both ready to prove they belong in this league.

Steelers vs Bills Over 47.5 (-110) at BetMGM

This bet is whether the final score of this game will add up to over or under what the oddsmakers predict, and in this case 46 points seem low for Week 5 of the NFL season when both offenses are warmed up and the defenses are getting tired.

Some stats to consider – the Buffalo Bills’ offense is ranked the third best in the league and scores 28.5 points per game whereas the Pittsburgh Steelers run the 30th ranked offense that scores 18.5 points per game – that alone gives you a lot to base your hunch upon.

On the other side of the ball, the Bills have the number one defense that keeps opponents to just 14.5 points per game while the Steelers’ defense is ranked 24th in the league and allows whatever team they play to score 22.5, so if both sides are healthy those numbers point to the under.

However, our guess is that this game will go over since the Buffalo Bills have QB Josh Allen with his trio of pass-catching playmakers – Gabe Davis, Stefon Diggs, and Isaiah McKenzie – while the Steelers rookie QB Kenny Pickett will no doubt get the green light from HC Mike Tomlin to make big things happen in his starting debut.

Bills Money Line (-900) at FanDuel

The oddsmakers are fairly certain the Buffalo Bills are going to win this one over the depleted Pittsburgh Steelers and are giving anyone with the nerve to bet on Pittsburgh about two touchdowns to sweeten the pot, a big red flag that this game is unbalanced.

Bills QB Josh Allen has helped his team climb to 3-1 but right now injuries are affecting this team with seven players listed as questionable for Week 5, a test of their roster depth as they face a rookie Steelers QB Kenny Pickett now starting for one of the winningest head coaches in NFL history, HC Mike Tomlin.

Let’s break down this wager so newer sports bettors understand how it works – you would have to bet $975 that the Buffalo Bills will win this game straight up in order to win $100 plus your initial bet back, which is risky but the perhaps way to go here.

That is because conversely, if you bet $100 that the Pittsburgh Steelers will upset the Buffalo Bills and win outright, you would win $675 plus your initial wager back, a tough bet to make unless you truly believe that the Pittsburgh Steelers could not possibly win four games in a row, even against these powerful Bills.

How to Watch Steelers vs Bills

What: Pittsburgh Steelers vs Buffalo Bills

Where: Highmark Stadium in Orchard Park, NY

When: Sunday, October 9, 2022; 1:00 PM ET

How: CBS