Seahawks vs. Cardinals Picks, Predictions & Player Props: Can the Cardinals Hold First Place?

• The Seattle Seahawks allow 120.3 rushing yards per game and 4.99 yards per carry. 

• The Arizona Cardinals average 149.9 rushing yards per game, which is fifth in the league. 

• Seahawks quarterback Geno Smith is fourth in the NFL in passing yards with 2,781 but is tied for first in interceptions with 11. 

The 6-4 Arizona Cardinals are on the road in Week 12 against the 5-5 Seattle Seahawks. The Cardinals are in first place in the NFC West, while the Seahawks are third in the same division.

Below are the odds for this game, my best bet, predictions, and best player props. 

Seahawks vs. Cardinals Odds 

Look below for the moneyline, point spread, and total odds courtesy of FanDuel Sportsbook, where new users can receive $150 in bonus bets after placing a winning $5 wager. 

Seahawks vs. Cardinals: My Pick

• My Pick: Cardinals Spread at -1.5 (-104) via FanDuel

Heading into this game, the Cardinals are not only coming off a bye, but they’ve also only allowed one passing touchdown over the last four games. 

Additionally, they’ve allowed just two rushing touchdowns to running backs since Week 5. 

The Seahawks have improved defensively, but I’m worried about their offense in this one. 

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Seahawks vs. Cardinals Predictions 

As the 1.5-point spread shows, this will be an incredibly close game. It’s a testament to how well the Cardinals have played this year that they’re slight favorites on the road in Seattle, of all places. 

I mentioned it above, but the Cardinals defense has kept touchdowns off the board recently. 

They’ve allowed just two rushing touchdowns to running backs since Week 5, and they’ve given up just a single passing touchdown over the last four games. 

They’ve also only allowed 15 points over the last two games, holding the New York Jets to six and the Chicago Bears to nine. 

The Seahawks are second in the NFL in passing yards per game at 260.9, but quarterback Geno Smith has 11 interceptions, which is tied for the most in the NFL. 

Turning back to the Cardinals to examine their offense, they’re averaging less than 200 passing yards per game, but where they excel is on the ground. They’re fifth in rushing yards per game at 149.9, which is fifth in the league. 

The Seahawks surrender 120.3 rushing yards (4.99 yards per carry) and nearly one rushing score per game to running backs. 

Look for the Cardinals to be able to run here while the Cardinals keep the Seahawks out of the end zone just enough. 

Teams score touchdowns in the red zone at a 48.57% rate against the Cardinals, which is seventh-best in the NFL. 

I could see a stat line for Smith with 275 passing yards, one touchdown, and one interception. 

I’ll take the Cardinals by a field goal. 

Seahawks vs. Cardinals Best Player Props

For prop bets, we are using odds from Caesars Sportsbook. New users at Caesars can receive a $1,000 first bet on Caesars with the use of our promo code WSN1000 during account registration. 

James Conner Over 69.5 Rushing Yards (-117 at Caesars Sportsbook)

Conner had just 33 rushing yards last week, but he’s had 70 rushing yards or more in half of his games this year, including four with 100 yards or more. 

So far this season, nine running backs have had 70 rushing yards or more against the Seahawks, and Los Angeles Rams running back Kyren Williams fell just short at 69 yards. 

Conner has had 18 carries or more in three of the last four games. He averages close to 16 carries per game, and with the Seahawks giving up nearly five yards per carry, those two figures put him at 80 yards. 

The Cardinals will want to run the ball here to keep the Seahawks' passing attack off the field, so expect Conner early and often. 

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Trey McBride Over 5.5 Receptions (+100 at Caesars Sportsbook)

Admittedly, I’m not 100% sold on this one, so I’d only go with a half-unit bet. 

That said, McBride consistently contributes to the Cardinals' offense, catching six passes or more in four of nine games. He’s averaging 5.4 catches per game. 

Here, he’ll face a Seahawks defense that surrenders about five catches for 51 yards to the position. From Weeks 2 to 8, they allowed six catches or more in five of seven games. The two that fell short were five catches. 

The last two weeks have featured tight end matchups against backups like Eric Saubert for the San Francisco 49ers and Davis Allen and Hunter Long for the Los Angeles Rams. 

At +100 value, it’s worth a go. 

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Kyler Murray Over 216.5 Passing Yards (-117 at Caesars Sportsbook)

While he’s averaging just 205.8 passing yards per game this season, Murray has been throwing the ball quite well over the past three weeks, throwing for 266 yards or more in two games. 

He’s had 217 yards or more in only three games this season. 

Taking on the Seahawks, they’re allowing 226.3 passing yards per game and have seen quarterbacks go for 217 or more in six of the last seven games. 

This game could certainly turn into a bit of a “you score, they score” feel with how close the spread is, so I’d expect Murray to throw perhaps a bit more than we’re used to, especially if Smith and the Seahawks come out hot on offense.

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Seahawks vs. Cardinals: How to Watch

• When: Sunday, Nov. 24  at 4:25 PM ET

• Where: Lumen Field in Seattle, WA

• Where to Watch: FOX

Seahawks vs. Cardinals Best Promos and Sportsbooks

If you’re looking for the best odds for the Seahawks vs. Cardinals matchup or any other Week 12 NFL game, check out our recommended NFL betting sites. FanDuel always delivers in moneyline and point spread odds, while Caesars always has dozens of player props for each game. 

Some of our favorite NFL betting promos can be found in the table below.

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Seahawks vs. Cardinals Injuries

• Seahawks tight end Noah Fant is questionable with a groin injury.

• Seahawks tight end Brady Russell is questionable with a foot injury. 

• Seahawks wide receiver Laviska Shenault Jr. is questionable with a back injury. 

• Seahawks cornerback Dee Williams is questionable with an ankle injury. 

• Seahawks defensive end Leonard Williams is questionable with a foot injury. 

• Cardinals defensive back Jalen Thompson is questionable with an ankle injury.

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