Seahawks vs. 49ers TNF Picks, Predictions & Player Props: Both Teams Look to Rebound From Losses

• The Seahawks lead the NFC West by one game

• The 49ers won five straight matchups against their rival

• Favorites won four of five Thursday Night Football games thus far

The Seattle Seahawks will kick off Week 6 by hosting the San Francisco 49ers in an NFC West battle on Thursday Night Football.

The Niners reached the Super Bowl last season and are favored to win the NFC Championship, though they’re just 2-3 with losses in three of their last four games. They just blew a 10-point fourth-quarter lead against the Arizona Cardinals last Sunday and do not look as steady as they have for the past half-decade.

The Seahawks dropped back-to-back games after winning their first three to start the season. They should be healthier than they have been recently, which figures to help them restore the defensive solidarity they showed during Weeks 1-3.

Here, we will analyze the betting odds and share our favorite Seahawks vs. 49ers betting picks and player prop bets.

Seahawks vs. 49ers Odds

The following odds for the Seahawks vs. 49ers matchup are provided by BetMGM Sportsbook. Place your bets at BetMGM and get up to $1,500 in bonus bets*

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Seahawks vs. 49ers Predictions 

The Seahawks adopted the image of their head coach, Mike MacDonald, the defensive coordinator of the Baltimore Ravens’ historic defense of a year ago and at the University of Michigan in years prior. They held teams to the seventh-fewest yards per play (5.0) and are ninth in third-down conversion percentage allowed, yet they’re just 17th in points allowed per game (22.8). 

Geno Smith completed a career-high 71.9 percent of his passes and leads the league in passing yards (1,466), though he only has five touchdowns to four interceptions. The team is also 22nd in rushing yards per game (105.4) despite ranking seventh in yards per carry (5.0).

San Francisco’s trademark cast of All-Stars has fallen on hard times in the young season. Numerous players, including Christian McCaffrey, Deebo Samuel, Talanoa Hufanga, and Fred Warner, have battled injuries, and the team has not lived up to expectations on either side of the ball.

The biggest disappointment for the reigning NFC champions is the defense. They fell from being one of the three best units in the league to 13th in EPA per play, which is an enormous decline.

Seahawks vs. 49ers Pick

• My Pick: 49ers to cover the spread (-3.5) at BetMGM

Underdogs have been great thus far, and there’s real value to betting on home teams during a short week. At the same time, favorites have dominated Thursday Night Football, and the trip from San Francisco to Seattle won’t affect the Niners players that greatly.

Seattle uncharacteristically gave up an average of 35.5 points over the last two weeks. That likely won’t happen again, though we also don’t believe the Niners will throw away a lead the same way they did against Arizona.

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Seahawks vs. 49ers Best Player Props

Brandon Aiyuk Anytime Touchdown Scorer (+150 at BetMGM)

Aiyuk had his best game of the season last week as he caught eight passes for 147 yards against Arizona. He started the season slowly after an offseason full of contract disputes with the front office and is yet to catch a touchdown, but last week’s performance was an indication that he’s back to full fitness and ready to get on the scoreboard.

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Jordan Mason Over 80.5 Rushing Yards (-125 at BetMGM)

Mason went over this line in four of five games, including each of his last two against the Cardinals and the New England Patriots. He averaged 107.2 yards and 21 carries per game and should continue to get plenty of looks in an offense that is built on running the ball and setting up the play-action. The Seahawks also rank 18th in yards per rush attempt defended (4.5).

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Geno Smith Under 252.5 Passing Yards (-115 at BetMGM)

Smith played the Niners three times since the start of the 2022 season and never threw for more than 238 yards, twice failing to even hit the 200-yard barrier. He’s been asked to throw the ball a ton lately and went over in four straight games, but Seattle has quietly found success running the ball and would be wise to put more emphasis into controlling the clock. 

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Seahawks vs. 49ers How to Watch

• When: Thursday, Oct. 10 at 5:15/8:15 p.m. PT/ET

• Where: Lumen Field, Seattle, WA

• Where to Watch: Prime Video

Seahawks vs. 49ers Best Promos and Sportsbooks

All of the best NFL betting sites have the 49ers listed as a 3.5-point favorite.

Anyone betting on the 49ers will find the best deal at bet365, where they have (+100) odds. Seahawks bettors will get the best deal at BetMGM who have them listed at +3.5 (-115).

All of the sportsbooks mentioned and more are giving out bonuses to customers who bet on the Seahawks vs. 49ers matchup. That includes BetMGM, which allows new bettors to get up to $1,500 in bonus bets.

More NFL betting promos and bonuses can be found in the table below.

*Bonus Bets Expire in 7 Days. One New Customer Offer Only. Add’l terms.

Seahawks vs. 49ers Injuries

San Francisco 49ers Injuries

• Charvarius Ward (CB) - Questionable (knee)

• Jake Moody (K) - Out

• Talanoa Hufanga (S) - Out (wrist)

• George Kittle (TE) - Questionable (ribs)

• Fred Warner (LB) - Questionable (ankle)

• Christian McCaffrey (RB) - Out (Achilles/calf)

Seattle Seahawks Injuries

• Uchenna Nwosu (LB) - Out (thigh)

• Byron Murphy II (DT) - Questionable

• Riq Woolen (CB) - Questionable (ankle)

• Derrick Hall (LB) - Questionable (foot)

• Julian Love (S) - Questionable (hamstring)

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