Best Parlay Picks for NFL Week 16: Good Week to Target Division Rivalry Games

• The Titans are 1-6 against the spread in the last seven games that they’ve been an underdog.

• Philadelphia has won 10 straight games, going 5-0 against the spread on the road during that streak.

• The Bills have scored at least 30 points in eight straight games.

The stretch run of the NFL season is officially here. In Week 16, things will start to get a little crazy with two games on Saturday and a full schedule on Sunday. That makes Week 16 a great time to think about a multi-leg parlay. After all, by this point in the season, we have a lot of information about every team and can make educated picks, even if it means having to tease spreads a little bit. 

Caesars Sportsbook is usually among the best NFL betting platforms for creating a parlay. There is a tool that makes it easy to tease spreads and point totals, making it easy to create a parlay that’s valuable but also has a chance to hit. Plus, Caesars currently has a welcome offer that lets you double your winnings on the next 10 bets after making an initial bet of just $1. Once you’ve placed that first bet, you can spend one of your 100% profit boosts - which doubles your profit on a bet - on a parlay. Even before any profit boost, the value of our Week 16 parlay is +517.

Not only can you take advantage of the welcome offer but Caesars will also make it easy for you to stream NFL Week 16 games for free right on the Caesars platform. This allows you to keep track of every leg of your parlay in real-time. In the meantime, you may want to look at how the current Super Bowl LIX odds and shaping up with three weeks left in the season. But let’s also take a closer look at the four legs of our Week 16 parlay.

Titans vs. Colts -4.5 (-110) at Caesars Sportsbook 

The Titans have been so bad that there should be no need to tease this spread. In the last seven games that Tennessee has been an underdog, the Titans are 1-6 against the spread. They are just 1-5 overall in their last six games with four of those five losses coming by at least 10 points. Defensively, the Titans are a disaster, while the Tennessee offense faces uncertainty after Will Levis was benched last week after throwing three interceptions. That doesn’t sound like the type of team that’s going to stay close on the road against a motivated Indianapolis team.

Despite a frustrating, turnover-plagued loss last week, the Colts are still in the playoff hunt. Indy has three winnable games to close out the season, so there is still hope. While it’s a small sample, the Colts have won and covered in the two games this season in which they’ve been home favorites. They’ve also won three straight games against the Titans and should be able to handle a Tennessee team that’s in shambles. If you want to be extra safe, take Indy’s moneyline, although this spread is small enough to feel comfortable with the Colts covering.

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Browns vs. Bengals -2.5 (-268) at Caesars Sportsbook 

At 6-8, the Bengals aren’t the most reliable team to back, especially as a favorite. That’s why we’re teasing this line down to a field goal. Cincinnati being 1-5 at home this season is also a concern. However, the Bengals have won and covered in back-to-back weeks, taking care of business against lesser teams. That makes us confident that they’ll be able to do the same this week. No matter the opponent, the Bengals have scored at least 27 points in six straight games, which is why covering a field goal is realistic for them.

Meanwhile, the Browns continue to look like a trainwreck. Cleveland’s snowglobe win over the Steelers a few weeks ago looks like a total aberration. Jameis Winston has thrown eight interceptions over his last three games, making it almost impossible to win games in the NFL. Losing Nick Chubb to a season-ending injury doesn’t help matters. With the Browns just 4-10 against the spread this season, teasing the line down to 2.5 points makes it even more likely that the Bengals can cover as part of this parlay.

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Eagles ML (-170) vs. Commanders at Caesars Sportsbook 

On paper, this is the toughest game the Eagles have had in a long time. But with 10 straight wins, the Eagles are on too much of a roll to stumble now. They are 7-3 against the spread during that stretch, including 5-0 against the spread on the road. Of course, with this being such a small spread, taking Philadelphia’s moneyline is a safer option without losing much value in our parlay. The Commanders could keep this game close, but the Eagles have every incentive to keep winning with the top seed in the NFC standings still within reach.

Granted, the Commanders have won back-to-back games after a three-game losing streak. However, wins over the Titans and Saints doesn’t prove that Washington is ready to beat an elite team. Washington has just one win over the Eagles in the last seven meetings between these teams. In fact, the Eagles have won six of their last seven road games against Washington. All signs point to the Commanders being a notch or two below the Eagles right now, which is why we feel comfortable with Philadelphia’s moneyline in this game.

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Patriots vs. Bills -9.5 (-208) at Caesars Sportsbook 

There is nothing that can stop the Buffalo offense right now. The Bills have scored at least 30 points in eight straight games, including 40-plus points in back-to-back games. Josh Allen looks close to solidifying his NFL MVP status, and with the Bills still in contention for the top seed in the AFC standings, they aren’t going to take their foot off the gas. To be fair, the Buffalo defense has sputtered the past two weeks, which is why we felt compelled to tease the spread below 10 points.

That being said, if the Bills can continue to score 30-plus points, the Patriots are going to have a hard time staying within 10 points of Buffalo. New England has failed to score more than 20 points in nine of its 14 games this season. It’s not as if things are starting to get better after a 30-17 road loss to the Cardinals last week. If the Buffalo defense can have a bounce-back game at home, the Patriots are likely to suffer a lopsided loss, which is why teasing the spread a little makes this a safe inclusion in our parlay.

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