NFC West Odds, Predictions, Betting Picks 2025: Rams Back on Top as the New Division Champions

• The Los Angeles Rams won the 2024-2025 NFC West division title

• The San Francisco 49ers entered the year as one of the betting favorites to win the Super Bowl

• The 49ers front seven ranks below league average in Def Rush DVOA, EPA, Success Rate, and Adjusted Line Yards

With the San Francisco 49ers dealing with an abundance of injuries, that opened the door for the rest of the field to claim the division title. The Los Angeles Rams eventually stood above the rest as they clinched the NFC West with their latest win over the Arizona Cardinals. When healthy, the Rams' offense was arguably one of the better units in the league this season as they head into the last week of the regular season ranked well above league average in Off DVOA, EPA, and Success Rate.

Speaking of the 49ers, they were ravaged by injuries this season which hurt their chances of remaining competitive. Reigning Offensive Player of the Year award winner Christian McCaffrey only made four appearances before going back on IR, Brandon Aiyuk tore his ACL early in the year, and Trent Williams was in and out of the lineup all season long while dealing with nagging injuries. Their lack of production on both sides of the ball was too much for them to overcome, resulting in the 49ers missing the playoffs.

NFC West Odds

Important note: Odds for NFC West are no longer available. Check back with us soon as we will continue covering NFC West in the 2025/26 season.

NFC West Predictions and Favorites to Win 

Even after battling through injuries earlier in the year, the Los Angeles Rams managed to overcome them and won the 2024-2025 NFC West division title.

Los Angeles Rams

Like the 49ers, the Rams also had to deal with injuries before the start of the regular season when Puka Nacua went down with a knee injury in training camp. Cooper Kupp also joined him on the sidelines a few weeks into the season, leaving Matthew Stafford void of their star-studded production. Even without his star duo, the Rams managed to stay afloat and remained in contention for the NFC West division title.

By winning the NFC West, the Rams have also secured a spot in the playoffs. Unfortunately for Los Angeles, making a run to the Super Bowl will be a tall task as their defense continues to play at a very low level. Heading into week 18, the Rams defense ranks in the bottom half of the board in Def DVOA, EPA, Success Rate, Adjusted Line Yards, and Adjusted Sack Rate. Unless their defense drastically elevates their level of play, then expect the Rams to make an early exit in the playoffs.

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Seattle Seahawks

When the 49ers were eliminated from division title contention, the Seattle Seahawks had a great chance to pull away from the rest of the pack as the sole leaders of first place. They were unable to hold on to their lead after losing two straight contests to the Green Bay Packers and Minnesota Vikings, giving the Rams the chance to leap over them in the division standings and secure the division title.

Not only have the Seahawks been eliminated from division title contention, but Seattle will also miss out on the playoffs as well. With their sights set towards the offseason, the Seahawks should focus on re-tooling their offense as they finish the year ranked below league average in Off DVOA, EPA, and Success Rate. With their receiving core intact, the Seahawks can attack their offensive line and running back room to help turn their offense into a more well-rounded unit.

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Arizona Cardinals

Even though the Arizona Cardinals held on to the top spot of the division for a few weeks earlier in the year, negative regression loomed large as they continued to receive minimal support from their defense. Their lack of defensive production was a thorn in their side this season all season long as the Cardinals head into the last week of the season ranked near dead last in Def EPA and Success Rate.

Should Arizona’s defense have managed to play at a higher level, then the Cardinals would have had a realistic chance of winning the division title as their offense grades out very well in Off DVOA, EPA, and Success Rate. Kyler Murray making his return from injury helped spark the Cardinals explosive offense, as well as surrounding him with a deep group of pass catchers. If Arizona successfully re-tools their defense this offseason, then expect them to compete for the division title next year.

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Who Will Win the NFC West - My Pick 

San Francisco 49ers

Not only did the San Francisco 49ers enter the year as the heavy-betting favorite to win the NFC West division title, but they were also listed near the top of the oddsboard for the Super Bowl as well. Unfortunately for San Francisco, an abundance of injuries derailed their plans of accomplishing both feats as the losses started to rack up at an alarming rate.

Injuries aside, the 49ers front seven also severely struggled in their efforts of stopping the run as they finish the year ranked well below league average in Def Rush DVOA, EPA, Success Rate, and Adjusted Line Yards. That hurt their chances of securing the win, especially while their offense consistently dealt with injuries. Even with health back on their side, the 49ers are in desperate need of more production from their defense should they want to round back into form and make a deep run in the playoffs next season.

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NFC West History

After a two year stretch in 2020-2021, the San Francisco 49ers have reclaimed their throne at the top of the NFC West. Unfortunately for San Francisco, they were unable to hold on to the title after an abundance of injuries derailed their season.

With the 49ers eliminated, the Rams are now the new betting favorite to win the division. As for the Seahawks, they are looking to get their 10th division title after winning it back in 2020. The Cardinals meanwhile are still in a rebuild and may be a few years away from actually contending in the division since winning it back in 2015.

Past NFC West Winners

How to Choose the Best Sportsbook for Betting on the NFC West

Acquiring as many sportsbooks as you can get is very important as it gives you the ability to line shop. Futures odds can drastically vary between sportsbooks as the Seahawks were listed as high as +235 at Caesars Sportsbook and as low as +180 at FanDuel Sportsbook to win the NFC West earlier in the year. That would have been a difference of $55 in profit for a $100 bettor should Seattle have won the division.

Another benefit of collecting sportsbooks is that each one has their own unique sign up bonus to help give a boost to your bankroll ahead of the start of the NFL season. BetMGM Sportsbook for example is giving new users up to $1,500 back in the form of bonus bets should you lose your first wager after creating an account with the WSN promo code WSNSPORTS.

Find more info in our detailed overview of the best NFL betting sites available today.

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How to Read NFC West Winner Odds

When making any type of wager, it’s vital to know how the listed odds work. Should you have made a wager on the 49ers to win the NFC West in the preseason at -180, then you would have had to wager $180 to profit $100 if they won the division. If you want to wager on one of the current contenders like the Seahawks at +235, then a $100 wager would profit you $235 should they have won the NFC West.