Monday Night Football Predictions & Best Bets Week 11

To close out Week 11 of the NFL season, we have an NFC West matchup—the San Francisco 49ers travel to take on the Arizona Cardinals.

According to ESPN’s Jeremy Fowler, Cardinals quarterback Kyler Murray missed Week 10, and there’s a sense that Murray could miss “another week or so.” 

The odds seem to indicate a potential Murray absence, but either way, we’ll do our best to examine it. 

Monday Night Football Best Bets

Cardinals +8 (-110) at DraftKings

The Cardinals are at home this week and getting eight points after putting up 27 against the Los Angeles Rams on the road with Colt McCoy at quarterback.

McCoy is a long-time veteran, and in his relief of Murray, he played quite well, completing 70.3% of his passes for 237 yards and one touchdown.

Per Pro Football Focus, he didn’t have a single turnover-worthy play, either. 

Of course, McCoy isn’t nearly as mobile as Murray, but he did have three designed runs, which does help with game-planning a Murray-less offense. 

The Cardinals are facing the best run defense in the league in terms of yards allowed per game. The 49ers allow less than 85 rushing yards per game. However, on the road, they do allow closer to 100. 

With DeAndre Hopkins back in the lineup, he’ll continue to be a force on offense. McCoy targeted him 14 times last week, and he caught 10 for 98 yards. 

The 49ers don’t have the best corners in the world, with Deommodore Lenoir lining up opposite Charvarious Ward.

Lenoir allows nearly 79% of his targets to be caught.

The 49ers have an offense capable of scoring on the Cardinals, and they will. The Cardinals allow nearly 300 passing yards per game at home.

We settle on the Cardinals here because eight points in a divisional matchup against a home team are too many points to give. McCoy should help the Cardinals sustain drives and keep this within eight. 

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Over 43.5 (-110) at Caesars

As mentioned, the 49ers will be able to score in this one with their plethora of weapons. The Cardinals allow a ton of yards passing at home, too. 

However, the Cardinals will also be able to score here, with Hopkins as the primary target, McCoy’s efficiency, and a somewhat-competent run game.

The 49ers are excellent against the run, but with Hopkins’s presence, we may see running back James Conner have a slightly better game than the average running back against them. 

Look for McCaffrey to have a great day running the ball and catching passes out of the backfield—the Cardinals also allow 122 rushing yards per game at home.

The 49ers will win this game 27-21.

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