Jaguars vs. Bills Picks, Predictions & Player Props: The Jaguars Are the Bills Kryptonite

• The 49ers are without wide receiver Deebo Samuel and running back Christian McCaffrey.

• The Rams are without star wide receivers Cooper Kupp and Puka Nacua. 

• The Rams have some pass-blocking help with Alaric Jackson and Logan Bruss potentially back in the lineup. 

The 0-2 Jacksonville Jaguars head out on the road to take on the 2-0 Buffalo Bills in this AFC Conference matchup. Below is my pick for this game, predictions, and top player props. 

Jaguars vs. Bills Odds 

Find the latest odds for the point spread, moneyline, and total odds for this matchup at FanDuel Sportsbook. FanDuel offers new players $200 in bonus bets when you sign up, deposit $10, and wager $5. 

Jaguars vs. Bills Pick

• My Pick: Bills Spread at -4.5 (-115) at FanDuel

There’s something about the Jaguars and Bills when they match up that just seemingly heavily favors the Jaguars. The Bills haven’t beaten them since 2018, and the Jaguars beat the Bills last season in Buffalo as underdogs, too. 

However, when you look at the current state of these teams, it simply favors the Bills. The Jaguars offense is stagnant, averaging 127.5 rushing yards (15th) and 167.5 passing yards (25th) per game. I still have long-term question marks for the Bills defense, but they’ve held up in the first two weeks. 

Take the Bills are home -4.5. 

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Jaguars vs. Bills Predictions 

The Jaguars defense gave Buffalo trouble last season and while there’s a chance they could here, I haven’t quite seen enough from them through the first two weeks to be overly concerned. They’ve notched 33 pressures and four quarterback sacks, but the Bills offensive line has also only allowed 11 pressures and no sacks. That said, they have only faced the Arizona Cardinals (arguably the worst pass rush in the league) and the Miami Dolphins in a blowout. 

Still, my biggest concern for the Jaguars here is the offense. Quarterback Trevor Lawrence has completed 26 of 51 passes (51%) for 382 yards and one touchdown. He’s averaging just 7.5 yards per attempt, and while he has no interceptions, he has two turnover-worthy plays. 

The Bills showed they could make plays in Week 2 on Thursday Night Football against the Miami Dolphins when they had three picks on quarterback Tua Tagovailoa. 

Lawrence may not be doing a whole lot well so far, but he’s pushing the ball downfield, completing seven of 11 throws 20+ yards for 212 yards and a score. Of his attempts, 21.6% of them are going downfield. 

The Bills defense has done a good job limiting big plays. They’ve allowed just 8.4 yards per reception. While the Cardinals didn’t do much to move the ball downfield, the Dolphins were trailing and had explosive weapons with Tyreek Hill and Jaylen Waddle. 

The Jaguars are holding teams closer to 100 rushing yards per game, and while that’s been the go-to for the Bills to start the year, they still have Josh Allen, who can pass the ball well as the Jaguars are allowing 245.5 passing yards (30th) per game. They’ve taken on the Dolphins and Cleveland Browns this season. 

I haven’t seen enough from the Jaguars to warrant picking them here. Lawrence’s downfield passing ability is noteworthy, but 4.5 points isn’t enough for me. 

Jaguars vs. Bills Best Player Props

James Cook Any Time TD (+135 at FanDuel Sportsbook)

While the Jaguars hold opposing running backs to 84 rushing yards and 3.73 yards per carry, they’ve shown some trouble against pass-catching running backs. In Week 1, they allowed seven catches for 76 yards to Dolphins running back De’Von Achane. Achane also had a rushing touchdown in that game. 

Cook is easily the most prominent asset in this Bills offense, averaging 15 carries for close to 75 yards per game. He’s averaging five yards per carry and had two rushing touchdowns in Week 2. He’s caught four passes for 49 yards and a touchdown in the passing game. 

While I wouldn’t quite consider Cook to be up there with Achane in terms of pass-catching running backs, Cook is unique in that he’s the focal point of the offense. Cook, Mack Holls, and Khalil Shakir all have one touchdown each. 

As a home favorite, look for Cook to get closer to 20 carries and be used in the passing game. He should score here. 

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Josh Allen Over 1.5 Passing TDs (-108 at FanDuel Sportsbook)

The Jaguars are allowing the 30th-most passing yards per game, and while that hasn’t exactly amounted to passing touchdowns to this point, they also haven't played a quarterback like Allen yet. 

Allen had two passing touchdowns in Week 1 and has shown an ability to get these passing touchdowns, even on limited attempts and yardage. 

I think Cook’s touchdown mentioned above could come in the passing game. From there, the Bills have a host of receivers to go up against a Jaguars defense that’s allowing opposing wide receivers 15 catches on 23 targets for 198 yards per game. 

The Bills don’t have a true No. 1, but that actually helps here as there’s no one for the Jaguars defense to zero-in on. 

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Brian Thomas Jr. Longest Reception Over 19.5 Yards (-113 at FanDuel Sportsbook)

The Bills have been quite good against opposing wide receivers this year, holding them to just 69.5 yards per game and 8.18 yards per catch, but I think Thomas Jr. has a chance to gash them for a long play here.

The Jaguars are underdogs on the road in a hostile environment. They’ll likely be trailing at numerous points throughout the game, and Thomas Jr. and Lawrence have shown a connection in the deep parts of the field. 

Remember, this catch only needs to go for 20 yards or more. Realistically, he could catch it and get yards after the catch. 

Still, Thomas has eight targets in the year, three of which have come 20+ yards downfield. He’s caught all three of them for 108 yards and a touchdown. He’s averaging 23.5 yards per reception, and Lawrence is completing over 63% of his passes, which are 20+ yards downfield. 

Thomas Jr. might see plenty of Christian Benford in this game. While he’s played well (allowed four catches on 10 targets for 25 yards), I think we still see some deep shots to Thomas Jr. here. 

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Jaguars vs. Bills How to Watch

• When: Monday, September 23 at 7:30 PM ET

• Where: Highmark Stadium in Orchard Park, NY

• Where to Watch: ESPN

Jaguars vs. Bills Best Promos and Sportsbooks

If you’re looking for other top NFL betting sites to browse odds for the Jaguars and Bills matchup or others, check out our list below, along with most current NFL promos and bonuses. For example, Caesars Monday Night Football Promo is already active, and we have listed more of our favorites in the table below.

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Jaguars vs. Bills Injuries

• Jaguars cornerback Tyson Campbell is on injured reserve with a leg injury. 

• Jaguars tight end Evan Engram is questionable with a leg injury. 

• Bills cornerback Taron Johnson is out with an arm injury. 

• Bills linebacker Terrel Bernard is out with a torso injury.

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