Chiefs vs. Chargers Prop Bets and Predictions: Chiefs Poised for an Upset

• The Chargers have several players listed on the injury report, including Rashawn Slater, Joe Alt, Joey Bosa, Justin Herbert, and more. 

• Nick Bolton, Rashee Rice, Jaylen Watson, and Derrick Nnandi were all full participants in practice for the Chiefs. 

• Chargers running back J.K. Dobbins is third in the NFL in rushing yards, averaging over seven yards per carry. 

In Week 4 of the NFL season, the Los Angeles Chargers host the Kansas City Chiefs in an AFC West showdown. The Chiefs are 3-0, while the Chargers are 2-1, coming off a loss to the Pittsburgh Steelers. 

Below, I’ll provide my pick, predictions, and top player props for this game. All odds are courtesy of Caesars Sportsbook.

Chiefs vs. Chargers Odds

Below are the moneyline, point spread, and total odds for the Chiefs vs. Chargers game. Sign up with Caesars Sportsbook with our promo code WSN1000 and get a $1,000 First Bet Offer OR $250 in Bonus Bets.

Chiefs vs. Chargers Pick

• My Pick: Chargers Spread at +7.5 (-110) at Caesars Sportsbook

While the Chargers are coming off a loss where they scored just 10 points, it happened on the road against the Steelers and with quarterback Justin Herbert getting injured. It appears he’ll suit up in Week 4 and take on a Chiefs team that’s had close calls in all three games. The Baltimore Ravens were out of bound by a toe to score the game-tying touchdown, the Bengals committed pass interference, allowing the Chiefs to kick the game-winning field goal, and the referees didn’t call pass interference on the Chiefs that would’ve put the Atlanta Falcons in position to score the go-ahead touchdown. 

The Chargers have a great running game and I think they lean on that here to keep the Chiefs offense on the field. Still, even with the Chiefs offense on the field, quarterback and NFL MVP odds favorite Patrick Mahomes has thrown for less than 200 yards in two straight games and close to 150 in Week 2.

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Chiefs vs. Chargers Predictions

The Chiefs are on the road here, taking on the Chargers, and the Chiefs have won the last five matchups. 

Starting with the offenses, the Chiefs average 25 points (seventh), 116.3 rushing yards (15th), and 211.7 passing yards (12th) per game. Mahomes is completing 69.6% of his passes for 659 yards, five touchdowns, and four interceptions. 

The running back room is without running back Isiah Pacheco for the foreseeable future and will look to Carson Steele as the primary runner. He had 17 carries for 72 yards in Week 3 against the Falcons. 

As for the pass-catchers, Rashee Rice leads the way with 29 targets, 24 receptions, 288 yards, and two touchdowns. Tight end Travis Kelce has just eight catches for 69 yards through three games. 

As mentioned, there have been many close calls for the Chiefs, and with a few things going the other way, they could be 0-3 or less than 3-0. 

Defensively, the Chiefs coverage unit has allowed four touchdowns, one interception, and five pass breakups. Rushing the passer, they have 55 pressures and eight sacks. 

The Chiefs injury report is clean, with linebacker Nick Bolton, Rice, cornerback Jaylen Watson, and defensive tackle Derrick Nnandi all listed as full participants in practice on Wednesday. 

They’ll take on a Chargers team that saw right tackle Joe Alt, left tackle Rashawn Slater, defensive tackle Joey Bosa, and linebacker Junior Colson all sitting out practice. Slater and Alt are expected to miss the game. 

Thus, the Chargers are headed into this game quite injured at key spots, but this is one of the best rushing offenses in the league, averaging 152 yards on the ground (seventh) per game. They’re the second-worst passing team, averaging just 125.7 passing yards per game. 

If Alt and Slater are out, it’ll be interesting to see who suits up as their tackles. It could be Foster Sarell and Trey Pipkins III, but again, it’s unclear. Also Pipkins III is also on the injury report. 

The Chargers have been hit with a plethora of injuries, but division games are also unique. We saw it with the Los Angeles Rams and San Francisco 49ers in Week 3. The 49ers were massive favorites and lost outright to a Rams team dealing with numerous injuries. 

I think the Chargers will play a safe brand of football, keep the score down, and cover at 7.5. A total of 40 with a point spread of 7.5 leaves little room for the Chiefs to cover, so I’ll take the home underdog.

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Chiefs vs. Chargers Best Player Props

Patrick Mahomes Under 17.5 Rushing Yards (+119) at Caesars Sportsbook

Mahomes has 49 rushing yards this season, including 17 in Week 3 and 29 in Week 2. He’ll take on a Chargers defense that holds opponents to 91.7 rushing yards per game (sixth-least). In addition, opposing quarterbacks average just 5.67 rushing yards per game against them. They’ve played Garnder Minshew, Bryce Young, and Justin Fields this season. Field had six carries for just six yards. 

If the game plays out the way the spread has it, the Chiefs will have a lead and will run plenty with Steele and Samaje Perine. I don’t think there will be a need for Mahomes to run. 

I’ll lean under here despite Mahomes going over this number in his last two games against the Chargers. 

Travis Kelce Over 45.5 Receiving Yards (-119) at Caesars Sportsbook

As I mentioned earlier, Kelce has been hardly involved in the offense, catching eight passes for 69 yards this year. He’s averaging just 8.6 yards per reception. He leads the team in receiving snaps but simply isn’t getting looked at a bunch. 

Through three games this season, opposing tight ends averaged six receptions for 42 yards and no touchdowns against the Chargers. This has come against the Raiders in Brock Bowers’ first NFL game, the Panthers with Young at quarterback, and the Steelers, who aren’t exactly a pass-first team. 

I think this is setting up to be a “Kelce game.” There’s a lot of talk about him not getting the ball as much, including on the broadcast during the Falcons game. 

Over his last five games against the Chargers, he’s had less than 100 yards in a game once, and in that game, he had 51 yards. 

I’m anticipating he’ll rebound here. 

J.K. Dobbins Any Time TD (+140) at Caesars Sportsbook

Dobbins is easily the most relied-upon asset in this Chargers offense, and with so many injuries, he’ll look to be the catalyst for their production. The Chiefs are allowing just 59 rushing yards per game to opposing running backs, but they’ve allowed two touchdowns despite the running backs not having a ton of production on the ground. 

Dobbins is third in the NFL in rushing yards with 310, only behind Saquon Barkley and Jordan Mason. He also has just 42 carries. He’s averaging 7.4 yards per carry and has two touchdowns. 

I think he’ll get plenty of volume, including in the passing game, where he has seven receptions, which should lead to a touchdown.

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Chiefs vs. Chargers How to Watch

• When: Sunday, September 29 at 4:25 PM ET

• Where: SoFi Stadium in Inglewood, California

• Where to Watch: CBS

Chiefs vs. Chargers Best Promos and Sportsbooks

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Chiefs vs. Chargers Injuries

• Chargers right tackle Joe Alt is questionable with a knee injury. 

• Chargers defensive end Joey Bosa is questionable with a hip injury. 

• Chargers linebacker Junior Colson is questionable with a hamstring injury. 

• Chargers quarterback Justin Herbert is questionable with an ankle injury. 

• Chargers wide receiver Joshua Palmer is questionable with an elbow and calf injury. 

• Chargers offensive lineman Trey Pipkins III is questionable with a foot injury. 

• Chargers left tackle Rashawn Slater is questionable with a pectoral injury.

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