Bills vs. Patriots Picks, Predictions & Player Props: This Could Get Ugly

• Patriots quarterback Drake Maye has thrown an interception in six straight games

• Bills quarterback Josh Allen has had five passing and five rushing touchdowns over the last two games

• Bills running back James Cook is tied for the second-most rushing touchdowns in the NFL with 13

The 11-3 Buffalo Bills will host the 3-11 New England Patriots in Week 16 of the NFL season. The Bills have already clinched the AFC East, while the Patriots, who are in the same division, are in last place. 

Below are the odds for this game, my best bet, predictions, and best player props.

Bills vs. Patriots Odds

Look below for the moneyline, point spread, and total odds courtesy of Caesars Sportsbook. Using our exclusive link and promo code WSNDYW, you’ll get your next 10 bets doubled in winnings after betting $1.

Bills vs. Patriots: My Pick

• My Pick: Bills to cover the spread at -14 (-115) at Caesars

The Bills have scored 30-plus points in eight straight games, while the Patriots average the second-lowest points per game at 17. 

The Bills are easily the better team here. 

The only reason to take the Patriots plus the points is because this is a divisional opponent, and the spread is so large. 

I don’t think the Patriots can keep up.

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Bills vs. Patriots Predictions 

The Bills have allowed 43 points per game over their last two, but that came against the Los Angeles Rams and Detroit Lions. 

These are two teams with a plethora of playmakers. 

The Patriots are the inverse of that—they’re looking for anyone to step up as a consistently high performer on offense. 

Patriots rookie quarterback Drake Maye has played well considering the team around him, but he has thrown an interception in six straight games. 

Again, he’s still excellent overall, but a turnover against the Bills will more than likely result in Buffalo scoring. 

As mentioned, the Bills have scored 30-plus points in eight straight games, averaging 35 points per game in that span. 

The Patriots are averaging 17 points per game and have scored 17 or less in eight games this season. 

In addition to how productive the Bills have been, quarterback Josh Allen has had five passing and five rushing touchdowns over the past two games. 

Speaking of rushing touchdowns, the Patriots allow nearly one per game to opposing running backs. Those same running backs are averaging close to 114 rushing yards per game and 4.62 yards per carry. 

The Bills will score almost at will at home. Take the them -14.

Bills vs. Patriots Best Player Props

James Cook Anytime Touchdown (-150) at Caesars Sportsbook

In Week 16, Cook has a chance to tie or surpass the current rushing touchdown lead in the NFL. 

He has 13 rushing scores, which is tied for second-most. 

Over his last five games, he’s scored six times. 

As mentioned, the Patriots allow opposing running backs nearly one rushing touchdown per game, including two last week. 

To be fair, they hadn’t allowed one before that since Week 8, but the Bills are a team that will run the ball plenty, and Cook will be the beneficiary of the group of running backs. 

Expect the Bills to be up big here, and Cook will help them run the clock out. 

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Josh Allen Over 1.5 Passing TDs (-160) at Caesars Sportsbook

The Patriots defense is allowing 1.57 passing touchdowns per game. However, over the last four games, they’ve allowed two touchdowns or more in three of them, including two games with four passing touchdowns. 

Allen has thrown multiple touchdowns in each of his last three games. 

There’s some worry here as the Bills could get up early via the run, leaving no need for Allen to throw. Still, throughout this season, Allen has thrown multiple touchdowns in nine games. 

This is a fairly easy matchup for the eventual NFL MVP of the league.

Get more Josh Allen prop bets for Week 16, right here.

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Drake Maye Over 0.5 INTs (-174) at Caesars Sportsbook

If the odds didn’t give it away, Maye will likely throw a pick this week. 

He’s thrown a pick in six straight games and is facing a Bills defense averaging nearly one pick per game. 

This season, Maye has nine interceptions but has 14 turnover-worthy plays. 

He’s been a bit lucky in the interceptions column. 

He has at least one pick in all but three games he’s played this season.

I expect the Patriots to be down a bunch, forcing Maye to throw. This will result in a pick.

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Bills vs. Patriots: How to Watch

• When: Sunday, Dec. 22 at 4:25 PM ET

• Where: Highmark Stadium in Orchard Park, NY

• Where to Watch: CBS

Bills vs. Patriots Best Promos and Sportsbooks

If you’re looking for the best odds for the Bills vs. Patriots matchup or any other Week 16 NFL game, check out our top recommended NFL betting sites. If you’re looking for the best point spread odds and player prop options, look no further than Caesars Sportsbook.

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Bills vs. Patriots Injuries

The following players have been marked as “did not participate” in practice so far this week.

• Patriots safety Kyle Dugger is questionable with an ankle injury. 

• Patriots running back JaMycal Hasty is questionable with an ankle injury. 

• Patriots cornerback Marcus Jones is questionable with a hip injury.

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