Best DeAndre Hopkins Prop Bets: Chiefs Are Underdogs Against the Bills

• DeAndre Hopkins has rejuvenated the Chiefs offense

• The Chiefs look to move to 10-0 on the season 

• Buffalo has the ninth-ranked defense in the NFL

The Chiefs are 9-0 after beating the Broncos on a blocked field goal as time expired. They now will face their toughest test this season against a strong Buffalo team.

DeAndre Hopkins has fit in perfectly with this offense, giving Mahomes a trusted weapon. Now that he is getting a majority of the snaps after learning the playbook, we expect him to have a huge week. 

We are targeting three Hopkins props that hold a ton of value over the course of the game.

FanDuel Sportsbook is one of the best NFL betting sites in the legal market, and the site has excellent lines for our three props. FanDuel gives new customers $150 in bonus bets if their first $5 wager wins on the platform.

DeAndre Hopkins Over 51.5 Receiving Yards (-114) at FanDuel 

Hopkins has the best quarterback in the NFL throwing him the ball so it’s always a great idea to take his receiving yards. He has 14 catches for 171 yards to go with two touchdowns since joining Kansas City. 

Hopkins has 344 receiving yards in 2024, but Tennessee did not utilize him like the Chiefs have thus far. Hopkins has lined up all over the field for this offense, and is getting comfortable at the right time. 

His catch ability in traffic is outstanding as he wins almost every one-on-one battle. Hopkins route running is also elite and we expect him and Mahomes to be ready to go against a rival like the Bills. 

Look for Hopkins to have his best game yet in Kansas City as the Chiefs always seem to find a new level against quality opponents. We think Hopkins easily clears this number and has a potential 100-yard receiving performance. 

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DeAndre Hopkins Over 4.5 Receptions (-105) at FanDuel

Hopkins is the primary receiver for the Chiefs, even compared to Travis Kelce. Andy Reid has built in play calls just for Hopkins whether it be short screens lined up wide, or slants across the field from the slot. 

Hopkins only had four receptions one week ago, after coming off a game the previous week in which he had eight catches. Kansas City already has a depth problem at receiver, and we think Hopkins will be the main focus. 

Patrick Mahomes has been smarter with the football in 2024 and dicing defenses. This can be good when targeting Hopkins’ receptions because Mahomes will be looking at him for quick hitters. 

Hopkins is a mismatch for any defender in the NFL with his great size and catch ability. In a game where Kansas City might be trailing, we like our chances for the receiver to surpass 4.5 receptions. 

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DeAndre Hopkins Anytime Touchdown (+190) at FanDuel 

Kansas City hasn’t been very efficient in the red zone as they have been settling for a ton of field goals. This is partially because of opponents taking away Kelce, which will leave Hopkins available for a one-on-one mismatch.

With great size, Hopkins is a huge threat, especially with Mahomes at quarterback. Mahomes has targeted Hopkins a ton in the red zone, but they have only connected twice for scores. 

It’s only a matter of time when we see Hopkins find the end zone again, and we think he will score in Week 11.  

This is a game that we see coming down to the final possession, and the team that finishes drives will ultimately win this game. Hopkins will be the main target for Kansas City this week and will get goal-line targets. 

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DeAndre Hopkins 2024 Stats

• Receptions: 29

• Receiving Yards: 344

• Touchdowns: 3