49ers vs. Vikings Prop Bets and Predictions: Christian McCaffrey Set to Miss Another Game

• The 49ers could be without running back Chrisitan McCaffrey once again as he deals with Achilles tendinitis. 

• The Vikings could be without wide receiver Jordan Addison, who’s dealing with a knee injury. 

• In relief of McCaffrey in Week 1, fellow running back Jordan Mason ran 28 times for 147 yards and one touchdown. 

In Week 2 of the NFL season, the San Francisco 49ers are on the road coming off a Week 1 Monday Night Football win to take on the Minnesota Vikings, who are also 1-0 after a win over the New York Giants. 

Below, I’ll examine the best prop bets for this matchup using odds from bet365 Sportsbook and predict who I think will win the game. By using our exclusive bet365 link, you’ll receive $200 in bonus bets when you bet $5 or receive your first wager back up to $1,000 if it loses. 

49ers vs. Vikings Predictions

The Vikings and new starting quarterback Sam Darnold did an excellent job against the New York Giants, including Darnold completing 19 of 24 passes for 208 yards, two touchdowns, and one interception. However, the 49ers defense could be a bit of a tougher task. Their defense held New York Jets running back Breece Hall to 3.4 yards per carry on 16 tries. However, they did allow two passing touchdowns, both to Allen Lazard, and here, they’ll have to deal with Justin Jefferson. 

Darnold is far from the best quarterback in the league, but this offense under head coach Kevin O’Connell operates in a way that puts the quarterback in the best possible position to succeed. It’ll be intriguing to see how 49ers wide receiver Brandon Aiyuk performs in Week 2 after a dropped pass in the endzone in Week 1 while battling a combination of cornerbacks, including Stephon Gilmore. 

Overall, I think the 49ers win here on the road even if running back Christian McCaffrey misses this game, but the Vikings offense does enough to keep this one close. Take the Vikings as the home underdogs at +6.5 and -115 odds.

49ers vs. Vikings Best Prop Bets

Below are the best prop bets for this 49ers and Vikings matchup.

Justin Jefferson Over 6.5 Receptions (-140) at bet365

Heading into this game, the health of wide receiver Jordan Addison has come into question as he’s dealing with an ankle injury. The latest report is that he’s dealing with “significant soreness” in his right ankle. If he misses this game, Jefferson should be peppered with targets. He saw seven targets and caught four of them in Week 1 in a blowout win. I expect this game to be a lot closer, or the Vikings will be trailing, forcing Darnold to throw more and more than likely to Jefferson, especially if Addison misses time. 

The receiver options after Jefferson and Addison are pretty bare. They include Josh Oliver, Ty Chandler, Jalen Nailor, and more. We could also see running back Aaron Jones have more receiving opportunities. 

I’d recommend getting this bet in before Addison is officially ruled out. If he’s ruled out, this could go up to 7.5 receptions or higher. 

Look for Jefferson to see double-digit targets here.

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Brock Purdy Under 0.5 Interceptions (-150) at bet365

Purdy played a clean game in Week 1, completing 19 of 29 passes for 231 yards. He didn’t throw a touchdown pass, but he didn’t have an interception against a Jets secondary with Sauce Gardner and D.J. Reed. 

When under pressure, he completed four of nine passes (44.4%) for 45 yards and averaged five yards per attempt. I think the 49ers offensive line with Trent Williams and Colton McKivitz should hold up fine in pass protection against Dallas Turner and Jonathan Greenard. Andrew Van Ginkel had a fantastic game in Week 1, but I was also encouraged by right guard Dominick Puni’s debut against the Jets. 

Even if McCaffrey is out with his Achilles tendinitis, we saw running back Jordan Mason play extremely well. He rushed 28 times for 147 yards and a score. 

I don’t think Purdy will face enough pressure to make a bad play, and the running game should relieve a lot of stress from this passing attack. 

This could be another game in which Purdy attempts 25 or fewer passes unless the Vikings' offense manages to come out firing.

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Aaron Jones Over 49.5 Rushing Yards (-110) at bet365

The 49ers allowed running back Breece Hall to rush 16 times for 54 yards and one touchdown. While Hall didn’t have a great yards-per-carry average, he topped this 49.5-yard prop. 

Sure, this is a different player, but I think the Vikings' offensive plan here will be similar to the 49ers against the Jets - keep the 49ers' offense off the field, complete easy passes, and run the ball effectively. 

Jones had 14 carries for 94 yards and a touchdown. He averaged 6.7 yards per carry and looked great against the Giants. 

The only thing that could hinder his overall rushing production is if Addison misses this game and the Vikings use his pass-catching abilities as an extension of the run game. 

Still, I’ll take the over here as I think this will be a focal point of the Vikings offense.

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49ers vs. Vikings: How to Watch

• What: 49ers vs Vikings Regular Season Week 2

• When: Sunday, September 15 at 1 PM ET

• Where: U.S. Bank Stadium

• How to Watch: CBS

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