wsn-newsletter Subscribe to WSN.

49ers vs. Lions MNF Picks, Predictions & Player Props: Old NFC Kings Host New NFC Heavyweight in Monday Night Finale

Contributors
Published December 29, 2024
8 min read
  • The Lions are 10-4-1 against the spread this season, as opposed to the 49ers, who are 5-10 against the spread, including 1-6 in their last seven games

  • Jahmyr Gibbs rushed for 109 yards on 23 carries last week in the first game of the season he didn’t share playing time with David Montgomery

  • Jared Goff has averaged 371 passing yards per game over his last three games

Week 17 of the season concludes with the final Monday Night Football Game of the year. The honor goes to the Detroit Lions and the San Francisco 49ers in a rematch of last season’s NFC Championship Game. The circumstances are a little different this time around with the 49ers out of playoff contention and the Lions still battling for the top seed in the NFC. Nevertheless, it’ll be a meaningful game and one that should generate a lot of interest from fans.

49ers vs. Lions Odds

This has not been San Francisco’s season, which is why the 49ers find themselves as home underdogs, which has been a rare occurrence for them in recent years. Of course, it doesn’t help that the 49ers have just one win in their last six games. That being said, they still have the respect of oddsmakers; otherwise, they would be underdogs by a lot more than 3.5 points against arguably the best team in the NFC. Here are the current odds for Monday’s game at bet365 Sportsbook:

Odds for Monday’s game at bet365 Sportsbook: Place your bets on the 49ers vs. Lions MNF matchup at bet365 and claim a bonus of your choice: $1,000 Safety Net Bet OR $150 in Bonus Bets.

TeamSpreadMoneylineOver/Under
San Francisco 49ers+3.5 (-115)+155Over 50.5 (-110)
Detroit Lions-3.5 (-105)-185Under 50.5 (-110)
Best NFL Sportsbooks
How We Rate
Affiliate Disclaimer
21+
49ers vs. Lions Predictions and Prop Bets

49ers vs. Lions My Pick

This spread is small enough to think that the Lions should be able to cover, even as the road team. Keep in mind that the Lions don’t have much margin for error if they want the top seed in the NFC, so they need to stay sharp. Detroit is also 10-4-1 against the spread this season, making the Lions a reliable favorite. On the other hand, the 49ers are 5-10 against the spread this year, including 1-6 against the spread in their last seven games. This late in the season, those trends provide more than enough data to bet on the Lions to win and cover.

Get $1,000 Safety Net Bet at bet365

49ers vs. Lions Predictions

Since Week 2, a loss to the Bills is the only blemish on Detroit’s season. Thus far, they’ve gone 7-0 on the road, winning five of those games by at least a touchdown. Late in the season, the Detroit offense shows no signs of slowing down, scoring at least 34 points in three straight games. The obvious caveat is the loss of David Montgomery to an injury. However, Jahmyr Gibbs can take on more carries while Detroit has enough receiving targets to lean more on Jared Goff and the passing game.

On the other side of the ball, the Detroit defense has been hit-and-miss this year. In games against quality offensive teams, the Lions have struggled, allowing 48 points against the Bills and 31 points in a close win against the Packers. However, Detroit still has a top-10 defense, yielding just 19.9 points per game on the season. But whether they can show up against a San Francisco team that has quality playmakers remains to be seen.

Of course, the San Francisco rushing attack has been hit hard by injuries this season. Third-stringer Isaac Guerendo has picked up the slack amidst injuries to Christian McCaffrey and Jordan Mason. But he’s questionable to play and battling an injury, missing last week’s game. With no other options, Brock Purdy and Deebo Samuel were the team’s leading rushers against the Dolphins last week. This leaves it up to Purdy to carry the offense with his arm.

Meanwhile, the San Francisco defense is facing its biggest challenge of the season. The 49ers are giving up 23.3 points per game on the season, falling well short of the standard that they’ve set for themselves in recent years. At times, we’ve seen flashes of the old San Francisco defense with the 49ers giving up 13 points or less in two of their last three games. However, the 49ers have also allowed 29 points or more in three of their last five games, struggling against quality offensive teams, which is exactly what they’ll face on Monday, which is why the Lions should be able to score enough points to cover the spread.

49ers vs. Lions Best Player Props

Jahmyr Gibbs Over 124.5 Rushing and Receiving Yards (-115) at bet365 Sportsbook

With David Montgomery out, Gibbs is the feature back, which should mean a lot of touches as both a rusher and pass-catcher. In his first full game without sharing time with Montgomery last week, Gibbs rushed for 109 yards on 23 carries. That’s an indicator of the workload and productivity to expect from him this week. He also had four catches for 45 yards last week. With or without Montgomery, Gibbs has recorded at least 30 receiving yards in three games. Combined with the production he’s likely to get on the ground, Gibbs’ rushing and receiving total should exceed 125 yards since he’ll be a pre-eminent part of the Detroit offense.

Use WSN365 for $1,000 Safety Net Bet at bet365

Jared Goff Over 250.5 Passing Yards (-110) at bet365 Sportsbook

Despite their losing record, the 49ers have allowed the second-fewest passing yards in the NFL this season. But Goff is also averaging 273 passing yards per game, so even a below-average performance could be enough to get him over 250 passing yards on Monday. He’s also on fire, averaging 371 passing yards per game over his last three games. Goff may not be able to reach those types of numbers against the 49ers, but he should be able to surpass 250 passing yards since the Lions might be more focused on the passing game with Montgomery out.

. Get $1,000 Safety Net Bet at bet365

George Kittle Under 69.5 Receiving Yards (-110) at bet365 Sportsbook

This is a big number for a tight end, even for someone as productive as Kittle. In fairness, he’s San Francisco’s leading receiver on the season and has reached at least 80 receiving yards in three of his last five games and five of his last eight games. However, the Detroit defense is allowing the fewest yards per game against opposing tight ends. Knowing the damage that Kittle has done in recent weeks, the Lions should be putting plenty of focus on him, helping to keep him below 70 receiving yards in this game.

Claim $150 in Bonus Bets at bet365

49ers vs. Lions How to Watch

  • When: 8:15 PM, EST on Monday, December 30

  • Where: Levi’s Stadium, Santa Clara, California

  • How to Watch: ESPN & ABC

49ers vs. Lions Best Promos and Sportsbooks

For every NFL game, one of the top sportsbooks to use is bet365. At bet365 Sportsbook, you’ll find a huge selection of bets and competitive odds, including player props. If you’re new to bet365, that’s good news because you’ll have your choice between $150 in bonus bets or having a safety net of up to $1,000 on your first wager. That’s what makes bet365 a great option for both experienced and novice bettors.

More of our favorite NFL betting promos can be found in the table below.

Sportsbook Promo Promo Code Sign Up Link
bet365 Sportsbook $1,000 Safety Net Bet OR $150 in Bonus Bets WSN365 Sign Up Here
BetMGM Sportsbook Get Up to $1,500 in Bonus Bets* WSNSPORTS Sign Up Here
BetRivers Sportsbook $100 Bonus Bet No code needed Sign Up Here
Caesars Sportsbook Bet $1, Double Your Winnings Your Next 10 Bets WSNDYW Sign Up Here
Crab Sports $500 First Bet Insurance WSNCRAB Sign Up Here
FanDuel Sportsbook Bet $5, Get $250 in Bonus Bets if Your Bet Wins No code needed Sign Up Here

*Bonus Bets Expire in 7 Days. One New Customer Offer Only. Add’l terms.

49ers vs. Lions Injuries

49ers Injuries

  • RB Christian McCaffrey (Injured Reserve)

  • RB Isaac Guerendo (Questionable)

  • WR Brandon Aiyuk (Injured Reserve)

  • OT Trent Williams (Injured Reserve)

  • OT Spencer Buford (Questionable

  • OG Jon Feliciano (Injured Reserve) 

  • DT Javon Hargrave (Injured Reserve)

  • DE Robert Beal Jr. (Questionable)

  • LB Dre Greenlaw (Out)

  • LB Dee Winters (Questionable)

  • S Ji-Ayir Brown (Questionable)

Lions Injuries

  • RB David Montgomery(Out) 

  • WR Kalif Raymond (Injured Reserve)

  • OG Graham Glasnow (Questionable)

  • DE Aidan Hutchinson (Injured Reserve)

  • LB Alex Anzalone (Injured Reserve)

  • LB Jalen Reeves-Maybin (Injured Reserve)

  • CB Charlton Davis III (Injured Reserve)

tip_r

Responsible Gambling

If you or someone you know needs support or wants to speak with a professional about responsible gambling, seek out the correct resources. Call or text 1-800-GAMBLER to get help, or visit 1800gambler.net for more information. WSN is an advocate for safe gambling practices. Visit our Responsible Gambling Center for more details.

Bryan Zarpentine WSN Contributor

Bryan Zarpentine

Sports Betting Analyst

Expertise:
MLB
NCAAB
NFL
Online Sports Betting
Bryan Zarpentine is a 2008 graduate of Syracuse University and has been working as a freelance writer and editor since 2010. During that time, he has contributed to countless sites while covering baseball, soccer, the NFL, college football, and college basketball.
Email: [email protected]
Nationality: American
Education: Bachelor of Arts
Favourite Sportsbook: BetMGM Sportsbook
Favourite Casino: BetMGM Casino
Experience: 14 years
We've been featured on:
espn logo
reuters logo
cbs-news logo
forbes logo
entrepreneur logo
entrepreneur logo
We only list licensed sportsbooks
WorldSportsNetwork
WorldSportsNetwork
WorldSportsNetwork
WorldSportsNetwork
WorldSportsNetwork
Co2neutral

We support responsible gambling. Gambling can be addictive, please play responsibly. If you need help, call 1-800-Gambler.

WSN.com is managed by Gentoo Media. Unless declared otherwise, all of the visible content on this site, such as texts and images, including the brand name and logo, belongs to Innovation Labs Limited (a Gentoo Media company) - Company Registration Number C44130, VAT ID: MT18874732, @GIG Beach Triq id-Dragunara, St. Julians, STJ3148, Malta.

Advertising Disclosure: WSN.com contains links to partner websites. When a visitor to our website clicks on one of these links and makes a purchase at a partner site, World Sports Network is paid a commission.

Copyright © 2025