Best College Football Bets Week 6 | CFB Picks & Predictions

The Week 6 college football slate has some big games on the calendar. Notre Dame will travel to Louisville to keep their momentum going after a close win over Duke last week. LSU also has a massive matchup against ranked Mississippi State. We’re breaking them both down in our picks article.  

We break down our best bets every week on WSN. Make sure to check back every Friday for the best college football bets on the slate!

#10 Notre Dame @ #25 Louisville 

• Date: Saturday, October 7
• Time: 7:30 pm EST
• Moneyline: Notre Dame (-230) | Louisville (+188)
• Spread: Notre Dame -6.5 (-105) | Louisville +6.5 (-115)
• Total: Over 54.5 (-110) | Under 54.5 (-110)

Odds via FanDuel Sportsbook. Bet $5, Get $200 in Bonus Bets using our exclusive link.

PICK: Notre Dame -6.5 (-105)

The Notre Dame Fighting Irish survived the Duke Blue Devils last week on the road. Notre Dame won 21-14, but it required a game-winning drive and one final defensive stop to ice the game. 

The Fighting Irish were the better team but struggled in multiple game phases. However, they ultimately found a way, largely thanks to Sam Hartman. Hartman is a fantastic quarterback, and he converted a long fourth-down run with the game on the line to lead the comeback. 

Audric Estime was also solid for the Irish last week, carrying the ball 18 times for 81 yards with two touchdowns. Louisville beat NC State 13-10 on the road last week, overcoming a 10-0 deficit. 

NC State is a solid opponent, but the Cardinals didn’t play well and should have won by more than three points. Yet, they haven’t played many quality opponents this season, meaning Notre Dame will be a massive test. 

We’re going to lay the points with the Fighting Irish at -6.5. If this line jumps to seven, we’ll still take Notre Dame, as they’re the much better team. The biggest difference in this game will be in the trenches, as the Irish have been dominant. 

Louisville has some explosive playmakers, but Jack Plummer has been turnover-prone, and Notre Dame’s defense will overpower the Cardinals. This shouldn’t be much of a game, so look for the Irish to easily cover the 6.5 points if they play up to their ability. 

#13 LSU @ #21 Missouri 

• Date: Saturday, October 7
• Time: 12:00 pm EST
• Moneyline: LSU (-144) | Missouri (+164)
• Spread: LSU -5.5 (-120) | Missouri +5.5 (-102)
• Total: Over 64.5 (-110) | Under 64.5 (-110)

Odds via FanDuel Sportsbook. Once you sign up at FanDuel, you'll get $200 in bonus bets to kick things off.  

PICK: LSU -5.5

LSU had a game to forget this past Saturday in Oxford, Mississippi. The Tigers were defeated by the Ole Miss Rebels 55-49. Jaxson Dart and the Rebels lit up Brian Kelly’s team in every aspect of the game. 

Ole Miss had 706 yards of total offense on the day, which included 317 yards on the ground. It was a dominant game from Ole Miss but an embarrassing showing from LSU. The Tigers blew a two-score lead in the game's final minutes because of their terrible defense. 

LSU has been able to survive this season because of their offense. Jayden Daniels is playing fantastic football and was great against Ole Miss. It wasn’t enough for the Tigers to overcome their defensive handicap, but we expect him to continue playing at a high level against Missouri. 

Missouri hasn’t played one challenging game, which is why they’re the 21st-ranked team in the country. They have beaten two Power Five teams in their five wins this year. Those programs were Kansas State, a decent Big 12 school, and Vanderbilt, a bad SEC team. 

Missouri should be able to score in this contest but look for LSU to play with a different energy on defense this week. We trust LSU to get back on track because of their terrible defensive effort one week ago. 

They’re more talented than Missouri, and we believe this game will resemble the one they played at Mississippi State a few weeks ago. The Tigers won 41-14 and dominated. Daniels should find Malik Nabers consistently throughout the game, and the defense has a better matchup on Saturday than last week in Oxford.