Knicks vs. Cavaliers Prediction and Odds: Anunoby Leads A Surging New York Side

The NBA’s Tuesday night schedule opens with a key Eastern Conference matchup between OG Anunoby’s shorthanded New York Knicks and Donovan Mitchell’s East-leading Cleveland Cavaliers. For new users at FanDuel Sportsbook, you can bet $5 and receive $200 in Bonus Bets if your bet wins!

For the best NBA game previews, WSN has you covered with betting picks and tips every day throughout the 2024-25 NBA season! New sports bettors supporting their hometown Cleveland Cavaliers can take advantage of the top Ohio sportsbook promos and bonuses before their matchup against the New York Knicks tips off!

The Knicks enter the second leg of a back-to-back on Wednesday night after OG Anunoby led their shorthanded squad to victory over the Knicks on Tuesday night! They’re hosted by the Cleveland Cavaliers, who are coming off an impressive win over the LA Clippers behind 24 points from Donovan Mitchell–the game tips off at 7:00 PM EST at Rocket Arena in Cleveland, Ohio.

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New York Knicks vs. Cleveland Cavaliers Betting Odds

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New York Knicks vs. Cleveland Cavaliers Betting Pick

• My Pick: Spread - Cleveland Cavaliers -11.0 (-110) at FanDuel

The New York Knicks and the Cleveland Cavaliers project to be contenders for the Eastern Conference crown this postseason. They’re unlikely to field their best lineups on Wednesday night, as both sides manage injuries, where the Cavaliers will have the decided advantage. Cleveland has defeated the Knicks twice this season, most recently by a 37-point margin. On the second leg of a back-to-back with two of their best players unlikely to take the court, expect the Cavaliers to take control on Wednesday night.

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New York Knicks Preview

The New York Knicks are seriously shorthanded, missing Jalen Brunson and Karl-Anthony Towns in their last game. On Wednesday, they’ll be on the second leg of a back-to-back against the Cavaliers as they attempt to go into the postseason on a winning run of form.

The Knicks boast a hard-charging, rim-attacking offense, averaging 116.4 points per game (9th of 30) and 27.5 assists (11th of 30) on 48.8% from the field (4th of 30). They allow just 112.1 points (10th of 30) while limiting their opponents to 42.0 rebounds per game (2nd of 30). They held the lowly Sixers to 91 points on 6 of 31 from deep while scoring 105 points themselves.

Through 75 regular season games this season, the New York Knicks have posted a 36-38-1 ATS Record, ranking them 18th in the NBA. They have a 48.7% cover percentage, a +4.5 margin of victory, and a -0.9 ATS +/- this season.

Keep an eye on OG Anunoby, who has led the Knicks in recent games, averaging 28.7 points, 4.8 rebounds, and 2.4 threes per game on 51.3% shooting and 37.8% from three-point range. He led the way in their previous game, a win over the Sixers, putting up 27 points, five rebounds, two made threes, and two steals in 33 minutes.

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Cleveland Cavaliers Preview

The Cleveland Cavaliers have been on an inconsistent streak to close the regular season but are back on the winning trend. They’ve split their last ten games and will host the Knicks in their previous home game before a short road trip out West.

The Cavaliers are first in the East behind their tremendous offense, leading the league with 122.3 points per game (1st of 30) on 49.2% from the field (2nd of 30) and 38.4% from three-point range (1st of 30). They’re no slouch on the defensive end, allowing 122.3 points (12th of 30) on 45.4% shooting (3rd of 30). They outpaced the Clippers in their last game, scoring 127 points on 50.5% from the field while hitting 15 threes.

Through 75 regular-season games, the Cleveland Cavaliers have posted a 44-30-1 ATS Record, ranking third in the NBA. They have a 59.5% cover percentage, a +10.0 margin of victory, and a +2.0 ATS +/- this season.

Donovan Mitchell is the player to watch when the Cavaliers face the Knicks, averaging 24.0 points, 4.9 assists, 4.5 rebounds, and 3.3 threes per game on 44.2% from the field and 36.6% from three-point range. He’s coming off a fantastic performance against the Clippers, putting up 24 points, 12 rebounds, seven assists, and two made threes on 47.4% shooting.

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New York Knicks vs. Cleveland Cavaliers Injury Report

• On Saturday, New York Knicks - (F) Kevin McCullar - Game Time Decision (Knee) - McCullar was inactive for the Knicks’ G-League affiliate.

• New York Knicks - (G) Jalen Brunson - Out (Ankle) - Brunson has been cleared for basketball activities and aims to return by the end of the regular season.

• New York Knicks - (C) Ariel Hukporti - Out (Knee) - There is no timetable for Hukporti’s return.

• New York Knicks - (G) Miles McBride - Out (Groin) - McBride has been out since March 20 and did not play in New York’s Tuesday game against the Sixers.

• New York Knicks - (G) Cameron Payne - Out (Ankle) - Payne will miss his third straight game when the Knicks play the Cavaliers on Wednesday.

• New York Knicks - (C) Karl-Anthony Towns - Out (Knee) - Towns missed the Knicks’ Wednesday night match against the Sixers with knee soreness.

• Cleveland Cavaliers - (G) Ty Jerome - Out (Knee) - Jerome will miss his fourth straight game when the Cavaliers face the Knicks on Wednesday night.

How to Watch New York Knicks vs. Cleveland Cavaliers

• Teams: New York Knicks vs. Cleveland Cavaliers

• Location: Rocket Arena, Cleveland, OH

• Date: 7:00 PM, Wednesday, April 2, 2025

• TV:  ESPN