San Diego FC vs. St.Louis City SC Prediction: Inaugural Home Opener for MLS' Newest Franchise

• San Diego FC’s introduction to MLS started with a famous win over their in-state rivals

• St.Louis City SC kicked off their fourth season with a scoreless draw against the Colorado Rapids

Saturday evening history will once again be made as the league's 30th club will host its first-ever home game. San Diego FC will welcome St.Louis City SC into hostile territory as this encounter will take place at Snapdragon Stadium. 

Here, we will break down the betting odds and share our favorite picks for San Diego FC vs. St. Louis City SC.

San Diego FC vs. St. Louis City SC Betting Odds for Saturday, March 1

With the indicated odds set for Saturday's tilt, the home side is pegged as the favorites to secure all three points. In the moneyline 3-way market, San Diego is priced at +115 while the visitors, St. Louis are listed at +200. If both sides are level after the final whistle, the draw is penned down at +280.

San Diego FC vs. St. Louis City SC Odds

The latest odds for the San Diego vs. St. Louis matchup can be found in the table below. Click the odds and bet on your favorites at some of the best soccer sportsbooks available today.

San Diego FC vs. St.Louis City SC Betting Prediction 

San Diego FC Preview 

The script could not have started any better for Mikey Varas’ men as they walked into the reigning champs den, garnering a 2-0 win over the LA Galaxy. SDFC locked down the 2024 MLS Cup winners, holding them to only three shots on target for the duration of their affair. 

Making history as the club's first goal scorer, Anders Dreyer will always have his name inked in record books with this expansion franchise. The 26-year-old followed up for good measure scoring a second tally versus the Galaxy. The winger has suited up for his home nation of Denmark at the senior level on three occasions, still in search of his first international goal. 

The marquee signing this newly arrived team made was getting the signature of Hirving Lozano to join the squad. The 29-year-old had a solid 88-minute debut in MLS collecting an assist while winning the most duels in the match with 12. Chucky Lozano has been a mainstay with his national side, Mexico, wearing El Tri colours on 70 occasions, cataloging 18 international goals. 

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St.Louis City SC Preview

Last Saturday was the introduction for Olof Mellberg on St.Louis’ touchline, managing his first match in MLS. His squad picked up a point at home, which felt more like a loss as St.Louis finished their encounter against the Rapids with an xG 2.01, completing 17 directed towards the net but lacked that final finish. 

In the home opener striker Joao Klauss failed to capitalize on his four cracks towards the net, with two landing on target. The 27-year-old has spent his entire MLS career with St.Louis, making 51 appearances across all competitive matches, netting 15 goals dating back to 2022. If this side is going to make a playoff push, Klauss needs to supply more goals. 

Marcel Hartel provided the most chances created in the march last Saturday with 70. During his full 90-minute stint, the winger obtained a single shot that missed the cage. The 29-year-old will look to build upon last season's stats which saw him retrieve three goals and five assists in nine MLS matches making his mid-summer move over from Germany. 

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San Diego FC vs. St.Louis City SC - My Pick

• San Diego FC vs. St.Louis City SC pick: San Diego FC moneyline 3-way (+115) at bet365

San Diego FC aren’t your typical expansion side that expects to go through growing pains, they are here to compete and make some noise which was on full display last week. SDFC are a pretty top-heavy team in attack versus their counterparts rolling into this weekend's clash. St.Louis was a terrible road team last season only managing to secure one win and at the same time struggled to defend as they conceded 42 away goals in 17 away trips. Besides a coaching change, St.Louis had a sporadic offseason bringing in new players, our belief is much won’t change this season for STLSC. We feel San Diego will have a nice advantage playing in front of their home fans for the first time, with the motivation to assemble that first home win.

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How to Watch San Diego FC vs. St.Louis City SC

• When: March 1, at 10:30 p.m ET

• Where: Snapdragon Stadium

• TV: Apple TV +, MLS Season Pass