Inter Miami CF vs. New York City FC Prediction: Messi and Co Look To Start 2025 With a Bang

• Inter Miami CF will look to replicate the previous term, finishing as the top side in MLS 

• NYCFC is confident in last year’s squad after a light winter transfer window. 

Well, the wait is finally over, MLS is back this weekend to kick off the 2025 campaign. Inter Miami CF hosts New York City FC at Chase Stadium in a marquee tournament opener. 

Here, we will break down the betting odds and share our favourite picks for Inter Miami CF vs. New York City FC.

Inter Miami CF vs. New York City FC Betting Odds for Saturday, February 22

The books have placed the home side as the firm favourite to acquire all three points in Saturday's tilt. Inter Miami are priced at -150 in the three-way moneyline market while NYCFC is listed at +333 to pull off the upset. If both clubs remain level after 90 minutes the draw is penned down at +320.

Inter Miami CF vs. New York City FC Odds

The following odds are taken from bet365 Sportsbook. Use our promo code WSN365 at bet365 to claim your bonus: Bet $5, Get $100 in Bonus Bets Win or Lose

Inter Miami CF vs. New York City FC Betting Predictions

Inter Miami CF Preview

In 2024 Inter Miami had every reason to claim their first MLS Cup, but ultimately crashed out in the first round of the playoffs in a major upset. Vice City is once again tabulated to claim the Philip F. Anschutz Trophy this year. This club remains loaded on the attack with the legend Lionel Messi leading the charge once again. 

The 2022 FIFA World Cup winner had a phenomenal first full season in MLS, bagging 21 goals in 22 outings. Messi also was able to provide 11 assists during his play on the pitch. Suffering an injury in the 2024 Copa America derailed the 37-year-old’s chance at a MLS Golden Boot title. Going into 2025 Messi will once again be leaned upon upfront on attack. 

Javier Mascherano had a decorated career as a player winning numerous titles with FC Barcelona. Now the former Argentina U20 and U23 head coach is the new dugout boss for Miami, hoping to lead them to glory following his compatriot Gerardo "Tata" Martina's failed attempt at a league championship. 

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New York City FC Preview

The Boys in Blue will also have a new advisor on the touchline guiding his side in 2025, as Pascal Jansen was appointed on January 6th. His previous coaching stints spanned from coaching club soccer in the Netherlands and Hungary. 

Alonso Martínez led the way finding the back of the net on 17 occasions during last year’s campaign in 30 league appearances. The Costa Rican international will be the focal point up front once again to provide the offence for NYCFC. Per 90 the 26-year-old was active with his boots averaging 3.27 shots per game, ranked in the top third amongst his peers. 

Santiago Rodriguez had a breakout 2024 season eclipsing previous highs in the goals department, cataloging 13 MLS goals. The attacking midfielder has 144 games of experience repping The Pigeons kit amassing 34 goals across all competitions played dating back to 2021. 

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Inter Miami CF vs. New York City FC - My Pick

• Inter Miami CF vs. New York City FC pick: Inter Miami CF three-way moneyline (-150) at bet365

Despite the historical trend that has NYCFC dominating the head-to-head battle as they have won eight of the previous 12 clashes in all competitive fixtures, we feel it’s worth backing the home side on Saturday afternoon. Inter Miami have won their last two home openers, and during the 2024 regular season, won 11 out of their 17 matches at Chase Stadium. Vice City are relatively healthy, meaning their big guns will be ready to go in game one of the year. Miami have had plenty of exhibition games under their belt, they should be the sharper side versus NYCFC.

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How to Watch Inter Miami CF vs. New York City FC

• When: February 22, 2.30 p.m ET

• Where: Chase Stadium

• TV: Apple TV +, MLS Season Pass