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Best MLB Prop Bets Today: Pitchers to Fade and Hitters to Target on Wednesday

Published: Apr. 16, 2025, 09:00 AM ET
5 min read
Best MLB Prop Bets Today April 16

Wednesday is shaping up to be an offensive-heavy day in the big leagues. For our prop picks, we’re fading a couple of pitchers and targeting a couple of hitters. Based on that, there are at least a few games that should see plenty of runs. Keep reading to find out who our targets are for Wednesday. 

For Wednesday’s prop bets, use bet365 Sportsbook. They always have competitive odds and a wide selection of prop bet choices. Plus, new customers have their choice of either $150 in bonus bets or a safety net of up to $1,000 on their first bet after signing up.

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Best MLB Prop Bets Today: Braves vs. Blue Jays (1:07 PM, EST)

Bryan De La Cruz Over 0.5 Hits (-165) at bet365 Sportsbook

De La Cruz has the odds of a player who’s hitless in four straight games and batting .186 on the season. However, he’s 6 for 10 with four extra-base hits in his career against Toronto starter Chris Bassitt. That’s an incredible track record against any pitcher, even in 10 at-bats. It’s the kind of history that makes De La Cruz a valuable pick to get a hit on Wednesday. Also, it was just last week that De La Cruz had a five-game hitting streak, collecting eight hits during that stretch. He’s capable of heating up and becoming a viable offensive threat for the Braves. Given his history against Bassitt, it’s worth taking a chance on him turning things around.

Chris Bassitt Over 17.5 Outs Recorded (-160) at bet365 Sportsbook

Aside from his struggles getting De La Cruz out, Bassitt has an excellent track record against most of Atlanta’s hitters. Bassitt has also yielded just two runs across 18.1 innings across his first three starts of the season. He’s given up 17 hits in that span, so teams have threatened to score against him, only for Bassitt to shut the door. The best option for him on Wednesday is betting on Bassitt to pitch at least six full innings. He’s done that in two of his three starts and was one out away from doing so in his last outing. In a day game, the Atlanta lineup should be a little sluggish, allowing Bassitt to get off to a strong start and have plenty in the tank to complete at least six full innings. Plus, given his strong track record against Atlanta, the Braves are unlikely to do enough damage to knock Bassitt out of the game early.

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Best MLB Prop Bets Today: Guardians vs. Orioles (6:35 PM, EST)

Dean Kremer Over 4.5 Hits Allowed (-105) at bet365 Sportsbook

The Orioles have to be concerned with Kremer’s start to the season. He’s rocking an ERA of 8.16 after three starts, taking the loss in his last two starts. Yet, things could be worse because Kremer has allowed 21 hits in just 14.1 innings. That includes giving up eight hits in each of his last two outings while failing to complete five innings in either start. That doesn’t bode well for Kremer’s chances on Wednesday against the Guardians, who have won six of their last seven games. The Guards have scored at least six runs and collected at least nine hits in four of their last five games, so they are heating up offensively at the moment. That gives us even more reason to fade Kremer, especially with virtually even odds for this bet.

Steven Kwan Over 1.5 Total Bases (+145) at bet365 Sportsbook

Kwan, in particular, has given Kremer a lot of problems in the past, making this a favorable matchup for him. He’s 4 for 8 with a double in his career against Kremer, so he’s had great success in a small sample size. Given Kremer’s struggles this season, Kwan should be poised to have a good game and collect multiple bases. It doesn’t hurt that Kwan is coming off a multi-hit game on Tuesday and is batting .333. As someone who’s usually a threat to compete for the batting title in any given year, he’s always a threat to have a multiple-hit game despite not always having a lot of power, which is why he’s worth the plus-odds for this type of bet.

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Best MLB Prop Bets Today: Rockies vs. Dodgers (10:10 PM, EST)

German Marquez Over 2.5 ER (-150) at bet365 Sportsbook

Marquez was brilliant in his first start of the season, throwing six scoreless innings against the Phillies. But that game looks like an aberration after his last two outings. He’s been knocked around for eight earned runs on 12 hits over 9.2 innings across those two starts. Even the A’s got the best of him, which makes it easy to fade him against the Dodgers. In fairness, Marquez has solid numbers against several members of the Los Angeles lineup. However, the Dodgers have had their way during the first two games of this series. With Shohei Ohtani and Mookie Betts at the top of the lineup, it’ll be hard for Marquez to survive multiple trips through the lineup without giving up a few runs.

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Bryan Zarpentine WSN Contributor

Bryan Zarpentine

Sports Betting Analyst

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Bryan Zarpentine is a 2008 graduate of Syracuse University and has been working as a freelance writer and editor since 2010. During that time, he has contributed to countless sites while covering baseball, soccer, the NFL, college football, and college basketball.
Email: [email protected]
Nationality: American
Education: Bachelor of Arts
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