Best MLB Parlay Picks Today: MLB Parlay for April 22
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Best MLB Parlay Picks Today: Strider Seeks Revenge Against St. Louis

Published: Apr. 22, 2025, 09:00 AM ET
4 min read
Best MLB Parlay Picks April 22

Spencer Strider and the Braves are one of the best parlay pieces on the Tuesday slate. The games are loaded with pitching advantages, which is perfect for a parlay. 

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Let’s dive into our three-leg parlay, which includes the Braves, Cubs, and Diamondbacks at +475.

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Cardinals vs. Braves (7:15 PM, EST)

Braves Moneyline (-136) at FanDuel Sportsbook

The Cardinals take on the Braves in Atlanta in a matchup featuring two teams that have struggled in 2025. St. Louis is 9-13 in the NL Central, while Atlanta is 8-13 in last place in the NL East

Andre Pallante gets the start for the Cardinals, and he is 2-1 with a 3.22 ERA in 2025. Pallante has struck out 15 batters in 22.1 innings, but he doesn’t get much run support. 

The Braves are going with Spencer Strider, who will make his second start of 2025. In his first outing, he went five innings, allowing two runs on five hits against Toronto. 

St. Louis is hitting .261 as a team this season, but they struggle against good pitchers, which is why I love this spot for Strider. I expect the Braves to wake up in Atlanta and for Strider to deliver a quality start on Tuesday. 

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Dodgers vs. Cubs (7:40 PM, EST)

Cubs +1.5 (-160) at FanDuel Sportsbook

The second-place Dodgers out of the NL West take on the first-place Cubs in the NL Central. This will be a matchup to watch, as both teams have started 2025 off hot. 

Los Angeles will start Dustin May, who is 1-1 with a 1.06 ERA. May is finally healthy and looking like himself again in 2025.

Chicago will go with Shota Imanaga, who is one of the best pitchers in baseball. Imanaga is 2-1 with a 2.22 ERA, and he has fanned 21 batters in 28.1 innings this season. 

This is a game where the Dodgers' offense might struggle against the left-handed pitcher, who keeps hitters off balance in Imanaga. 

The Cubs are sixth in baseball in team batting average, hitting .258 as a team, and they will need to scratch a few runs off May early in this contest. 

Trust the Chicago offense and Imanaga to get the job done in covering the run-line against Los Angeles. 

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Rays vs. Diamondbacks (9:40 PM, EST)

Diamondbacks Moneyline (-156) at FanDuel Sportsbook

To close out the parlay, we are taking the Diamondbacks on the moneyline against the Rays. Arizona is 13-9 in fourth place in a loaded NL West division, and Tampa Bay is 9-13 in the AL East

The Rays will start Zack Littell, who is winless on the year at 0-4 with a 5.48 ERA. Arizona’s offense will score runs early and often in this favorable matchup against Littell. 

Brandon Pfaadt gets the ball for the Diamondbacks, and he is 3-1 with a 3.04 ERA in 2025. In his last 11.2 innings, he has only allowed one run on nine hits while striking out nine. 

The Rays are top five in team batting average, but they are at a disadvantage with Littell on the mound for them on Tuesday. 

We expect Arizona to get a quality start from Pfaadt and for the offense to have a field day against Littell and the Rays. 

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Tanner Kern

Tanner Kern

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