Pumas UNAM vs. Club America Prediction: Clasico Capitalino Hostilities Renew

• Pumas are off to a subpar start, currently sitting in ninth place in the 2025 Clausura table. 

• Club America have gone two matches in a row without a win, looking to snap their mini skid in this derby. 

Saturday evening we get our first marquee derby in Liga MX with the Clasico Capitalino, with Pumas welcoming Club America in enemy territory. The most recent skirmish saw Pumas win 1-0 on the road in a temper-filled match during the Apertura campaign. 

Here, we will break down the betting odds and share our favorite picks for Pumas UNAM vs. Club America. 

Pumas UNAM vs. Club America Betting Odds for Saturday, February 22

With the indicated odds, the books feel both sides can breach each keeper in Saturday's tussle. For both teams scoring it’s listed at -125 while both teams not scoring is priced at -106. 

Pumas UNAM vs. Club America Odds

Latest odds for the Pumas UNAM vs Club America matchup can be found in the table below. Click the odds and bet on your favorites at some of the best soccer sportsbooks available today.

Pumas UNAM vs. Club America Betting Prediction 

Pumas UNAM Preview 

Last Sunday Gustavo Lema’s men suffered their second league defeat, this time losing to Pachuca at Estadio Hidalgo. The 2-1 setback saw Pumas failing to generate any dangerous attacking opportunities as they finished the game with an xG of 0.36. 

Checking in as a second-half substitute, Ignacio Pussetto broke Pachuca’s clean sheet bid, scoring in stoppage time. The 29-year-old has had six domestic outings in 2025, the striker has managed to hit the back of the net on three occasions. 

On a monetary note, Adalberto Carrasquilla was one of the club's big signings in the winter window. Through 389 minutes logged, the midfielder has yet to create anything up front as Carrasquilla has zero goal contributions so far. The 26-year-old has represented his home nation of Panama on the international stage in 61 instances, tallying two goals.

Bet $5 at bet365 and Get $100 in Bonus Bets

Club America Preview 

After a white-hot start to the 2025 Clausura season, suddenly André Jardine’s troops have stalled, disappearing from the win column. Las Águilas in a midweek affair participated in a high-profile match that saw the top two teams in the competitions go toe-to-toe, finishing in a 1-1 draw against first-place Club Leon. 

Off to a great start to the tournament, Alex Zandejas keeps on finding his way onto the scorers' sheet. Including his tally versus Leon, the American midfielder has cataloged four goals and three assists in six matches in 2025. Suiting up for the Mexican giants on 133 occasions since January 2022, the 27-year-old has amassed 39 goals across all competitions played. 

Due to his regular standards, 2025 has been a bit of a slow start for Henry Martin. Setting up Las Águilas’ lone goal on Wednesday, the striker filed his third assist of the season. Martin had one of his better performances of the year during his midweek showing, appearing in the full 90 minutes, and finishing the match with the most chances created with three. 

Get $100 in Bonus Bets When Betting $5 at bet365

Pumas UNAM vs. Club America - My Pick

• Pumas UNAM vs. Club America pick: Both teams to score YES (-125) at bet365 

Despite five of the last seven Clasico Capitalino has seen both clubs failing to score inside the full-time whistle, we feel on Saturday this altercation should see both sides get onto the scoreboard. With Club America playing on Wednesday, we feel this opens up the opportunity for Pumas to take advantage of fatigued legs.

Rolling into this clash, both clubs possess strong scoring trends as the hosts have bagged eight goals in their last five fixtures at the same time the visitors are carrying the hot boot, scoring 12 goals in their last five. With the current circumstances between both adversaries and the trends in the league overall with both teams scoring in Liga MX matches, our thoughts are that Saturday's discord should be no different.

  Claim $100 in Bonus Bets at bet365 With a $5 Wager

How to Watch Pumas UNAM vs. Club America

• When: February 22, 10.05 p.m. ET

• Where: Estadio Olímpico Universitario

• TV: FOX Deportes, Univision, UniMas, Telemundo, Universo, TUDN, ESPN Deportes, ESPN+ and ViX+