Atletico San Luis vs. Chivas Guadalajara Prediction: Can San Luis End Their Losing Streak

• Currently, Atletico San Luis sits in the basement of the standings, only collecting three points through eight matches

• Chivas will look to climb up the table as they seek their fourth victory in the 2025 Clausura

Wednesday evening one of the league's most decorated clubs, Chivas Guadalajara will travel down to Estadio Alfonso Lastras to clash against Atletico San Luis. Their most recent encounter occurred in the previous term, which saw San Luis win in enemy territory obtaining a 1-0 win. 

Here, we will break down the betting odds and share our favourite picks for Atletico San Luis vs. Chivas Guadalajara.

Atletico San Luis vs. Chivas Guadalajara Betting Odds for Wednesday, February 26

In the tie no bet market, the books have indicated that visitors are more likely to avoid a defeat in Wednesday’s tilt. Chivas are priced at -163 while the hosts, San Luis are penned down at +120.

Atletico San Luis vs. Chivas Guadalajara Odds

Latest odds for the Atletico San Luis vs. Chivas Guadalajara matchup can be found in the table below. Click the odds and bet on your favorites at some of the best soccer sportsbooks available today.

Atletico San Luis vs. Chivas Guadalajara Betting Prediction

Atletico San Luis Preview

The misery continued on Saturday for Domènec Torrent’s men as they were drubbed in a 3-1 losing cause versus C.F. Monterrey. Inside the 90-minute frame, San Luis couldn’t generate much offence as they were severely outshot by a wide margin of 21 to six.

Shattering the opposition's clean sheet bid on Saturday, Vitinho managed to sneak one past the keeper in the 87th minute. The 23-year-old came on as a substitute for the first time this campaign as he previously started seven matches in a row. The attacking winger joined his current employers in June of 2022, bagging 15 goals in 92 appearances across all competitions.

Dealing with a tumultuous period between the sticks, Andreas Sanchez’s numbers are inadequate through his seven starts. The keeper currently possesses a 2.43 goals against average while owning a 46.4 save percentage, both currently near the bottom in Liga MX. The 27-year-old is currently projected to get the nod once again in goal on Wednesday.

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Chivas Guadalajara Preview

Oscar Garcia’s crew put themselves in a difficult spot on Saturday, conceding an early goal but responded with two consecutive goals. Chivas had to play the final stretch of the match down to 10 men, hanging on for a 2-1 home win against Pachuca.

Rejoining Chivas after his four-year MLS stint with Sporting Kansas City, Alan Pulido found the tying marker versus Pachuca. His tally was his second goal of the year in his fourth 2025 Clausura outing. The 33-year-old striker is dangerous in most of his shifts as he amassed 41 goals in all competitions during his first spell with the Sacred Herd dating between 2016 to 2019.

Representing Mexico’s national team on 54 occasions, Luis Romo was Chivas’ big addition this winter offseason. The reliable midfielder managed to score his first goal in Chivas colours on Saturday, turning out to be the winning goal. The 29-year-old has logged 454 minutes in the tournament so far, acquiring his first assist back on February 9.

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Atletico San Luis vs. Chivas Guadalajara - My Pick

• Atletico San Luis vs. Chivas Guadalajara pick: Chivas Guadalajara tie no bet (-163) at bet365

Despite the mismatch on paper, weekday fixtures can be a little trickier to dive into which is why we are taking the safer route in the tie no bet market. Our belief is that Chivas is still the predominant side here as they have only suffered two defeats in their last eight visits to Estadio Alfonso Lastras. The Striped goats are hitting the back of the net consistently, recording nine in their last five affairs. San Luis has struggled to keep the ball out of their net, failing to secure a clean sheet in their last 10 attempts. We feel this is a good spot for the Sacred Herd to establish their class, grabbing their first road result this season, facing the worst side in Liga MX.

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How to Watch Atletico San Luis vs. Chivas Guadalajara

• When: February 26, 10.05 p.m. ET

• Where: Estadio Alfonso Lastras

• TV: FOX Deportes, Univision, UniMas, Telemundo, Universo, TUDN, ESPN Deportes, ESPN+ and ViX+